Displaying drugs 1076 - 1100 of 1429 in total
SR-9009
SR-9009 is a REV-ERB agonist. SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues .
Experimental
Matched Synonyms: … -Pyrrolidinecarboxylic acid, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-, ethyl …
Matched Iupac: … ethyl 3-({[(4-chlorophenyl)methyl][(5-nitrothiophen-2-yl)methyl]amino}methyl)pyrrolidine-1-carboxylate …
Matched Description: … SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent ... cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues [A32628 …
Matched Iupac: … ethyl 3-({[(4-chlorophenyl)methyl][(5-nitrothiophen-2-yl)methyl]amino}methyl)pyrrolidine-1-carboxylate …
Matched Description: … SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent ... cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues [A32628 …
SNS-314
SNS-314 is a potent and selective inhibitor of Aurora kinases A, B, and C. Proliferating cells treated with SNS-314 bypass the mitotic spindle checkpoint and fail to undergo cytokinesis, leading to multiple rounds of endoreduplication and eventually cell death. SNS-314 inhibits tumor growth in a variety of preclinical models, and...
Investigational
Matched Synonyms: … 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea …
Matched Iupac: … 1-(3-chlorophenyl)-3-{5-[2-({thieno[3,2-d]pyrimidin-4-yl}amino)ethyl]-1,3-thiazol-2-yl}urea …
Matched Description: … SNS-314 is a potent and selective inhibitor of Aurora kinases A, B, and C. ... , leading to multiple rounds of endoreduplication and eventually cell death. ... Proliferating cells treated with SNS-314 bypass the mitotic spindle checkpoint and fail to undergo cytokinesis …
Matched Iupac: … 1-(3-chlorophenyl)-3-{5-[2-({thieno[3,2-d]pyrimidin-4-yl}amino)ethyl]-1,3-thiazol-2-yl}urea …
Matched Description: … SNS-314 is a potent and selective inhibitor of Aurora kinases A, B, and C. ... , leading to multiple rounds of endoreduplication and eventually cell death. ... Proliferating cells treated with SNS-314 bypass the mitotic spindle checkpoint and fail to undergo cytokinesis …
2'-fluoro-5-ethylarabinosyluracil
2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and Recurrent Mantle Cell Lymphoma, among others.
Investigational
Matched Synonyms: … 2'-Fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil …
Matched Description: … Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Description: … Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
(5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol-2-one
Experimental
Matched Name: … (5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol …
Dovramilast
Dovramilast is under investigation in clinical trial NCT01300208 (To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus).
Investigational
Matched Synonyms: … Cyclopropanecarboxamide, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro ... N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2- (methanesulfonyl)ethyl]-3-oxo-2,3-dihydro-1H-isoindol- 4-yl ... N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl} …
Matched Description: … trial NCT01300208 (To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and ... Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus …
Matched Description: … trial NCT01300208 (To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and ... Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus …
S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea
Experimental
Matched Name: … S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea …
[2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid
Experimental
Matched Name: … [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid …
Matched Iupac: … [2-(N-hydroxyformamido)ethyl]phosphonic acid …
Matched Iupac: … [2-(N-hydroxyformamido)ethyl]phosphonic acid …
ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate
Experimental
Matched Name: … ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate …
Matched Iupac: … ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate …
Matched Iupac: … ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate …
N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDE
Experimental
Matched Name: … N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDE …
Matched Iupac: … 1-{2-[4-(4-carboxybutanamido)phenyl]ethyl}piperidin-1-ium-1-olate …
Matched Iupac: … 1-{2-[4-(4-carboxybutanamido)phenyl]ethyl}piperidin-1-ium-1-olate …
Lapatinib
Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a...
Approved
Investigational
Matched Synonyms: … N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl …
Matched Description: … anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and ... Lapatinib is a human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and ... Lapatinib is a human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Amelubant
Investigational
Matched Synonyms: … -[[4-[[3-[[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenoxy]methyl]phenyl]methoxy]phenyl]iminomethyl]-, ethyl …
Matched Iupac: … ethyl N-(4-{[3-({4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy}methyl)phenyl]methoxy}benzenecarboximidoyl …
Matched Iupac: … ethyl N-(4-{[3-({4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy}methyl)phenyl]methoxy}benzenecarboximidoyl …
TAK-075 Free base
Investigational
Matched Synonyms: … Pyrazolo(1,5-a)pyrimidine-3-carboxamide, n-(1-ethyl-1-(4-ethylphenyl)propyl)-4,5,6,7-tetrahydro-2,7,7 …
Darifenacin
Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence.
Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention.
It is unknown if M3 receptor selectivity is clinically...
Approved
Investigational
Matched Synonyms: … (S)-1-(2-(2,3-dihydro-5-benzofuranyl)ethyl)-α,α-diphenyl-3-pyrrolidineacetamide …
Matched Iupac: … 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide …
Matched Description: … This block reduces the urgency to urinate and so it should not be used in people with urinary retention …
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence …
Matched Iupac: … 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide …
Matched Description: … This block reduces the urgency to urinate and so it should not be used in people with urinary retention …
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence …
Mitotane
Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the...
Approved
Matched Synonyms: … 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene …
Matched Iupac: … 1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene …
Matched Description: … itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and ... It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma[A263010] and is …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Iupac: … 1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene …
Matched Description: … itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and ... It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma[A263010] and is …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
N-acetylserotonin
Experimental
Matched Synonyms: … N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)acetamide …
Matched Iupac: … N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide …
Matched Iupac: … N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide …
Melatonin
Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about...
Approved
Nutraceutical
Vet approved
Matched Synonyms: … N-[2-(5-methoxyindol-3-yl)ethyl]acetamide …
Matched Iupac: … N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide …
Matched Description: … Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. ... , fertility and reproduction. ... Lerner of Yale University is credited for naming the hormone and for defining its chemical structure …
Matched Categories: … Hypnotics and Sedatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Iupac: … N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide …
Matched Description: … Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. ... , fertility and reproduction. ... Lerner of Yale University is credited for naming the hormone and for defining its chemical structure …
Matched Categories: … Hypnotics and Sedatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
RS-39604
RS-39604 is a selective 5-HT4 receptor antagonist.
Investigational
Matched Synonyms: … Methanesulfonamide, n-(2-(4-(3-(4-amino-5-chloro-2-((3,5-dimethoxyphenyl)methoxy)phenyl)-3-oxopropyl)-1-piperidinyl)ethyl …
Matched Iupac: … N-{2-[4-(3-{4-amino-5-chloro-2-[(3,5-dimethoxyphenyl)methoxy]phenyl}-3-oxopropyl)piperidin-1-yl]ethyl …
Matched Iupac: … N-{2-[4-(3-{4-amino-5-chloro-2-[(3,5-dimethoxyphenyl)methoxy]phenyl}-3-oxopropyl)piperidin-1-yl]ethyl …
ABSK-091
Investigational
Matched Synonyms: … Benzamide, n-(5-(2-(3,5-dimethoxyphenyl)ethyl)-1h-pyrazol-3-yl)-4-((3r,5s)-3,5-dimethyl-1-piperazinyl …
Matched Iupac: … N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide …
Matched Iupac: … N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide …
1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM
Experimental
Matched Name: … 1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM …
Matched Iupac: … 2,4,6-trimethyl-1-[2-(4-sulfamoylphenyl)ethyl]pyridin-1-ium …
Matched Iupac: … 2,4,6-trimethyl-1-[2-(4-sulfamoylphenyl)ethyl]pyridin-1-ium …
5'-S-[2-(decylamino)ethyl]-5'-thioadenosine
Experimental
Matched Name: … 5'-S-[2-(decylamino)ethyl]-5'-thioadenosine …
Matched Iupac: … (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-({[2-(decylamino)ethyl]sulfanyl}methyl)oxolane-3,4-diol …
Matched Iupac: … (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-({[2-(decylamino)ethyl]sulfanyl}methyl)oxolane-3,4-diol …
2-[(2-NAPHTHYLSULFONYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE
Experimental
Matched Name: … 2-[(2-NAPHTHYLSULFONYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE …
Amlodipine
Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called dihydropyridine calcium channel blockers. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities...
Approved
Matched Synonyms: … (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate ... 3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate …
Matched Iupac: … 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Description: … Amlodipine is commonly used in the treatment of high blood pressure and angina. ... dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and ... Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), …
Matched Mixtures name: … Amlodipine Besylate and Benazepril Hydrochloride ... Amlodipine besylate and benazepril hydrochloride ... Amlodipine besylate and benazepril hydrochloride …
Matched Categories: … ACE Inhibitors and Calcium Channel Blockers ... Angiotensin II Antagonists and Calcium Channel Blockers ... Calcium Channel Blockers and Diuretics ... Calcium-Regulating Hormones and Agents ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers …
Matched Iupac: … 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Description: … Amlodipine is commonly used in the treatment of high blood pressure and angina. ... dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and ... Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), …
Matched Mixtures name: … Amlodipine Besylate and Benazepril Hydrochloride ... Amlodipine besylate and benazepril hydrochloride ... Amlodipine besylate and benazepril hydrochloride …
Matched Categories: … ACE Inhibitors and Calcium Channel Blockers ... Angiotensin II Antagonists and Calcium Channel Blockers ... Calcium Channel Blockers and Diuretics ... Calcium-Regulating Hormones and Agents ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers …
Telacebec
Investigational
Matched Synonyms: … 6-chloro-2-ethyl-n-((4-(4-(4-(trifluoromethoxy)phenyl)-1-piperdinyl)phenyl)methyl)-imidazo(1,2-a)pyridine ... Imidazo(1,2-a)pyridine-3-carboxamide, 6-chloro-2-ethyl-n-((4-(4-(4-(trifluoromethoxy)phenyl)-1-piperidinyl …
Matched Iupac: … 6-chloro-2-ethyl-N-[(4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methyl]imidazo[1,2-a]pyridine …
Matched Iupac: … 6-chloro-2-ethyl-N-[(4-{4-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}phenyl)methyl]imidazo[1,2-a]pyridine …
Chiglitazar
Chiglitazar is under investigation in clinical trial NCT06125587 (Chiglitazar/metformin in Non-obese Women With PCOS).
Investigational
Matched Synonyms: … O-(2-(9h-carbazol-9-yl)ethyl)-n-(2-(4-fluorobenzoyl)phenyl)-l-tyrosine ... L-tyrosine, o-(2-(9h-carbazol-9-yl)ethyl)-n-(2-(4-fluorobenzoyl)phenyl)- …
Dezapelisib
Dezapelisib is under investigation in clinical trial NCT02456675 (INCB040093 and INCB040093 Combined With Itacitinib (INCB039110) in Relapsed/refractory Hodgkin Lymphoma).
Investigational
Matched Synonyms: … 6-(3-fluorophenyl)-3-methyl-7-[(1S)-1-(7H-purin-6-ylamino)ethyl]-[1,3]thiazolo[3,2-a]pyrimidin-5-one …
Matched Iupac: … 6-(3-fluorophenyl)-3-methyl-7-[(1S)-1-[(9H-purin-6-yl)amino]ethyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5 …
Matched Description: … Dezapelisib is under investigation in clinical trial NCT02456675 (INCB040093 and INCB040093 Combined …
Matched Iupac: … 6-(3-fluorophenyl)-3-methyl-7-[(1S)-1-[(9H-purin-6-yl)amino]ethyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5 …
Matched Description: … Dezapelisib is under investigation in clinical trial NCT02456675 (INCB040093 and INCB040093 Combined …
Displaying drugs 1076 - 1100 of 1429 in total