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Displaying drugs 1076 - 1100 of 1507 in total

Golimumab

Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with...
Approved
Matched Description: … Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients ... Golimumab binds and inhibits soluble and transmembrane human TNFα. ... Additionally in children and adolescents taking golimumab, there have been lymphoma and other malignancies …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Biologics for Rheumatoid Arthritis Treatment …
Matched Products: … Concentrate for Solution for Infusion 12.5mg/1 ml ... SIMPONI IV 12.5mg/1ml Concentrate for Solution for Infusion ... SIMPONI SOLUTION FOR INJECTION …

Allopurinol

Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals . Allopurinol is a xanthine oxidase enzyme inhibitor that...
Approved
Matched Description: … This disease has been well-documented in historical medical records and appears in the biographies of ... It was initially approved by the FDA in 1966 [L5674] and is now formulated by several manufacturers [ ... enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and …
Matched Salts name: … Allopurinol sodium …
Matched Products: … Allopurinol sodium ... MEDIURIC FORTE …

Insulin glulisine

Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by ... Type 1 and Type 2 Diabetes. ... Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. …
Matched Categories: … Insulins and Analogues for Injection, Fast-Acting ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … APIDRA 100 Units/ml Solution for Injection in vial ... APIDRA 100 U/ML- SOLUTION FOR INJECTION IN VIAL ... Apidra SoloStar 100 Units/ml Solution for injection in a pre-filled pen …

Guselkumab

Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in...
Approved
Investigational
Matched Description: … In clinical trials, guselkumab demonstrated improved skin clearance and symptomatic improvements in dermatological ... market name Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis. ... Developed by Janssen, the subcutenous injection form of guselkumab was approved in July 2017 under the …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …
Matched Products: … TREMFYA 100MG/ML SOLUTION FOR INJECTION ... Tremfya One-Press 100mg/ml Solution for Injection ... TREMFYA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML …

Emicizumab

Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three different factors allows it to overcome immunogenicity and unstable...
Approved
Investigational
Matched Description: … Emicizumab was originated as an improved form of hBS23 and it was approved on November 16, 2017. ... Ltd. and co-developed with Roche and Genentech.[L1015] ... it has the capacity to bind simultaneously to activated Factor IX and Factor X. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Matched Products: … HEMLIBRA 30MG/ML SOLUTION FOR INJECTION ... HEMLIBRA 150MG/ML SOLUTION FOR INJECTION ... HEMLIBRA SOLUTION FOR INJECTION 30MG/ML …

Afoxolaner

Experimental
Vet approved
Matched Mixtures name: … Nexgard Spectra 38mg/8mg Chewable Tablets for Dogs >7.5-15kg ... Nexgard Spectra 9mg/2mg Chewable Tablets for Dogs 2-3.5kg ... Nexgard Spectra 19mg/4mg Chewable Tablets for Dogs >3.5-7.5kg …
Matched Products: … NexGard 11mg chewable tablets for dogs 2-4kg ... NexGard 136mg chewable tablets for dogs > 25-50kg ... NexGard 28mg chewable tablets for dog > 4-10kg …

Agalsidase alfa

Agalsidase alfa is a recombinant human α-galactosidase A similar to agalsidase beta. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater benefit with agalsidase beta.[A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa,...
Approved
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Matched Products: … REPLAGAL CONCENTRATE FOR SOLUTION FOR INFUSION 1 MG/ML …

Risankizumab

Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease.[L39885,L44191,L44231] Risankizumab...
Approved
Investigational
Matched Description: … It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and ... [A254716] Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease. ... [L39885,L44191,L44231] Risankizumab is being investigated for atopic dermatitis.[A254716] …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …
Matched Products: … SKYRIZI SOLUTION FOR INJECTION IN PRE-FILLED PEN 150MG/ML ... SKYRIZI SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 75MG/0.83ML ... SKYRIZI SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 150MG/ML …

Letermovir

Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplant patients. It is the first of a new class of CMV anti-infectives called DNA terminase complex inhibitors. Letermovir has recieved both priority and orphan drug status...
Approved
Investigational
Matched Description: … [A31290] Letermovir has recieved both priority and orphan drug status from the FDA. ... Letermovir recieved approval from the FDA on November 8th, 2017 for use in prophylaxis of cytomegalovirus …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … PREVYMIS CONCENTRATE FOR SOLUTION FOR INFUSION 20MG/ML ... PREVYMIS 240mg/12mL (20mg/mL) concentrate for solution for infusion ... PREVYMIS 480mg/24mL (20mg/mL) concentrate for solution for infusion …

Avibactam

Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Description: … As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 ... infections in combination with metronidazole, and the treatment of complicated urinary tract infections ... This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal …
Matched Salts name: … Avibactam sodium …
Matched Products: … ZAVICEFTA POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 2G/0.5G …

Tetrofosmin

Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.
Approved
Matched Products: … MYOVIEW POWDER FOR INJECTION ... MYOVIEW FOR INJECTION 0.23 mg/vial …

Olipudase alfa

Olipudase alfa is recombinant human acid sphingomyelinase. It is the first and only enzyme replacement therapy in the world for the treatment of Acid Sphingomyelinase Deficiency (ASMD), also known as Niemann–Pick disease. ASMD is a rare lysosomal storage disease caused by mutations in the SMPD1 gene, leading to a deficiency...
Approved
Investigational
Matched Description: … [A251590] It is the first and only enzyme replacement therapy in the world for the treatment of Acid ... storage disease caused by mutations in the SMPD1 gene, leading to a deficiency in acid sphingomyelinase and ... to hydrolyze sphingomyelin accumulated in body tissues, such as the lungs, liver, spleen, kidneys, and …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Matched Products: … XENPOZYME 20MG POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION …

Trastuzumab deruxtecan

Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of...
Approved
Investigational
Matched Description: … The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from ... A188988] Trastuzumab deruxtecan was developed by Daiichi Sankyo in collaboration with AstraZeneca and ... Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … ENHERTU POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/VIAL …

Anifrolumab

Anifrolumab, or MEDI-546, is a type 1 interferon receptor (IFNAR) inhibiting IgG1κ monoclonal antibody indicated in the treatment of adults with moderate to severe systemic lupus erythematosus.[A237074,L34929] The standard therapy for systemic lupus erythematosus consists of antimalarials like hydroxychloroquine, glucocorticoids like dexamethasone, and disease modifying antirheumatic drugs like methotrexate.[A237079,L34929] Three...
Approved
Investigational
Matched Description: … [hydroxychloroquine], glucocorticoids like [dexamethasone], and disease modifying antirheumatic drugs ... [A237079,L34929] Three monoclonal antibodies (anifrolumab, [rontalizumab], and [sifalimumab]) that ... The design of early clinical trials of anti-interferon treatments such as anifrolumab, rontalizumab, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … SAPHNELO 300MG CONCENTRATE FOR SOLUTION FOR INFUSION …

Obinutuzumab

Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV)...
Approved
Investigational
Matched Description: … It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. ... There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … GAZYVA 1000 MG/ 40 ML CONCENTRATE FOR SOLUTION FOR INFUSION ... GAZYVA CONCENTRATE FOR SOLUTION FOR INFUSION 1000MG/40ML …

Necitumumab

Necitumumab is an intravenously administered recombinant monoclonal IgG1 antibody used in the treatment of non-small cell lung cancer (NSCLC) as an EGFR antagonist. It functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands, a process that is involved in cell proliferation, metastasis, angiogenesis, and...
Approved
Investigational
Matched Description: … Necitumumab is approved for use in combination with cisplatin and gemcitabine as a first-line treatment ... It functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands ... , a process that is involved in cell proliferation, metastasis, angiogenesis, and malignant progression …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … PORTRAZZA CONCENTRATE FOR SOLUTION FOR INFUSION 800MG/50ML …

Eptinezumab

Eptinezumab is a fully-humanized IgG1 antibody manufactured using yeast (Pichia pastoris) and developed by Lundbeck Seattle Biopharmaceuticals. Eptinezumab has been specifically designed to bind to both alpha and beta forms of the human calcitonin gene-related peptide (CGRP).[F94,A33105,A33106,A33108] It was approved by the FDA in February 2020 for the preventive treatment...
Approved
Investigational
Matched Description: … [L12318] Eptinezumab has been specifically designed to bind to both alpha and beta forms of the human ... Eptinezumab is a fully-humanized IgG1 antibody manufactured using yeast (_Pichia pastoris_) and developed ... [F94,A33105,A33106,A33108] It was approved by the FDA in February 2020 for the preventive treatment of …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … VYEPTI CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/ML …

Amivantamab

Amivantamab, also known as JNJ-61186372, is an anti-EGFR-MET bispecific antibody, derived from Chinese hamster ovary cells, approved for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose...
Approved
Investigational
Matched Description: … [A235103,L34193] Patients with NSCLC often develop resistance to drugs that target EGFR and MET individually ... FDA approval on 21 May 2021,[L34193] followed by the approval by the EMA on 9 December 2021 [L41474] and ... Patients with NSCLC with exon 20 insertion mutations in EGFR do not respond to tyrosine kinase inhibitors, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … RYBREVANT 350mg/7mL Concentrate for Solution for Infusion …

Galcanezumab

Galcanezumab is a humanized monoclonal antibody developed by Eli Lilly and Company against human calcitonin gene-related peptide (CGRP). Although several small-molecule CGRP receptor antagonists have been developed, humanized monoclonal antibodies like galcanezumab are specifically designed to selectively bind to CGRP entities with high potency. Given this target specificity, lack of...
Approved
Investigational
Matched Description: … [A33112] Galcanezumab was approved by the FDA in September 2018, and is indicated for the preventive ... promising safety and tolerability. ... treatment of migraine and the treatment of episodic cluster headache. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … EMGALITY SOLUTION FOR INJECTION IN PRE-FILLED PEN 120 MG/ML ... Pontevia 120 mg solution for injection in pre-filled pen ... EMGALITY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 100 MG/ML …

Daunorubicin

A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Approved
Matched Description: … , used in treatment of leukemia and other neoplasms. ... A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others …
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... cytarabine and daunorubicin ... Cytotoxic Antibiotics and Related Substances …
Matched Products: … DAUNOCIN FOR INJ ... DAUNOCIN FOR INJECTION 20 mg/vial ... DAUNOBLASTINA FOR INJECTION 20 mg/vial …

Decitabine

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia. Further mutations leading to increased proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a poor prognosis.[A215082, A215092] Among treatment options, nucleoside analogues such as...
Approved
Investigational
Matched Description: … approved by the FDA for the treatment of MDS on February 5, 2006. ... and related downstream therapeutic benefits. ... presentation, including neutropenia and thrombocytopenia. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … DACOGEN (Decitabine) 50 mg Powder for Concentrate for Solution for Infusion ... Redtibin (Decitabine) Powder for Injection 50mg/vial …

Tigecycline

Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S. Food and Drug Administration (FDA) on June 17, 2005.
Approved
Matched Description: … Food and Drug Administration (FDA) on June 17, 2005. ... Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Tigaciv 50mg Lyophilized Powder for Concentrate for Solution for Infusion ... TIGECYCLINE SANDOZ POWDER FOR SOLUTION FOR INFUSION 50 MG PER VIAL ... TIGAR 50 (Tigecycline Powder for Solution for Infusion 50mg/Vial) …

Levodropropizine

Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
Investigational
Matched Description: … Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and …
Matched Categories: … Cough and Cold Preparations …
Matched Products: … LEVOZOPIN FORT 60MG/5ML ŞURUP, 75 ML ... LEVOPRONT FORT 60 MG/5 ML ŞURUP, 75 ML ... LEVOSOL FORT 60 MG / 5 ML ŞURUP, 75 ML …

Bortezomib D-mannitol

Approved
Matched Products: … Bortezomib for Injection ... Bortezomib for Injection Sdz …

Interferon beta-1a

Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta.
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Matched Products: … Rebif 22mcg/0.5ml solution for injection ... Rebif 44mcg/0.5ml solution for injection ... Rebif Solution for Injection in Cartridge 22mcg/0.5ml …
Displaying drugs 1076 - 1100 of 1507 in total