Displaying drugs 13126 - 13150 of 13944 in total
Thymectacin
Thymectacin, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine, is a novel small molecule anticancer agent. Thymectacin is selectively active against tumor cells expressing high levels of thymidylate synthase (TS), a critical enzyme in DNA biosynthesis. Thymectacin was as efficacious as irinotecan, a drug recently approved for the treatment of 5-fluorouracil-resistant colon cancer.
Investigational
Matched Iupac: … methyl (2S)-2-[({[(2R,3S,5R)-5-{5-[(E)-2-bromoethenyl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}-3- ... hydroxyoxolan-2-yl]methoxy}(phenoxy)phosphoryl)amino]propanoate …
Matched Description: … Thymectacin, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine, is a novel small molecule ... Thymectacin is selectively active against tumor cells expressing high levels of thymidylate synthase (TS), a ... Thymectacin was as efficacious as irinotecan, a drug recently approved for the treatment of 5-fluorouracil-resistant …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Thymectacin, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine, is a novel small molecule ... Thymectacin is selectively active against tumor cells expressing high levels of thymidylate synthase (TS), a ... Thymectacin was as efficacious as irinotecan, a drug recently approved for the treatment of 5-fluorouracil-resistant …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Pipequaline
Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It presents a unique chemical structure that does not follow the structural properties of other drugs of its class. Pipequaline has a similar pharmacological profile to the reported for the benzodiazepines. However, it...
Experimental
Matched Synonyms: … 2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline …
Matched Iupac: … 2-phenyl-4-[2-(piperidin-4-yl)ethyl]quinoline …
Matched Description: … However, it presents a significant set of anxiolytic properties with a very little sedative, amnestic ... Due to these differences, this drug is classified as a nonbenzodiazepine anxiolytic. ... Pipequaline has a similar pharmacological profile to the reported for the benzodiazepines. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … 2-phenyl-4-[2-(piperidin-4-yl)ethyl]quinoline …
Matched Description: … However, it presents a significant set of anxiolytic properties with a very little sedative, amnestic ... Due to these differences, this drug is classified as a nonbenzodiazepine anxiolytic. ... Pipequaline has a similar pharmacological profile to the reported for the benzodiazepines. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
(3R,4R,5S,6R)-6-Fluoro-3,4,5-trihydroxytetrahydro-2H-pyran-2-olate
Experimental
Matched Name: … (3R,4R,5S,6R)-6-Fluoro-3,4,5-trihydroxytetrahydro-2H-pyran-2-olate …
Matched Iupac: … (3R,4R,5S,6R)-6-fluoro-3,4,5-trihydroxyoxan-2-olate …
Matched Iupac: … (3R,4R,5S,6R)-6-fluoro-3,4,5-trihydroxyoxan-2-olate …
3-Hydroxy-4-(3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy)-piperidin-2-one
Experimental
Matched Name: … 3-Hydroxy-4-(3,4,5-trihydroxy-tetrahydro-pyran-2-yloxy)-piperidin-2-one …
Matched Iupac: … (3S,4R)-3-hydroxy-4-{[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}piperidin-2-one …
Matched Iupac: … (3S,4R)-3-hydroxy-4-{[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}piperidin-2-one …
Sacituzumab tirumotecan
Sacituzumab tirumotecan is a recombinant humanized IgG1 anti-TROP2 monoclonal antibody conjugated to a topoisomerase I inhibitor.
Investigational
Matched Description: … a topoisomerase I inhibitor. ... Sacituzumab tirumotecan is a recombinant humanized IgG1 anti-TROP2 monoclonal antibody conjugated to …
Osanetant
Developed by Sanofi-Aventis (formerly Sanofi-Synthelabo), osanetant (SR-142801) is an NK3 receptor antagonist which was under development for the treatment of schizophrenia and other Central Nervous System (CNS) disorders. In a review of its R&D portfolio, the company announced in August 2005 that it would cease any further development of osanetant....
Investigational
Matched Iupac: … N-(1-{3-[(3R)-1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl}-4-phenylpiperidin-4-yl)-N-methylacetamide …
Matched Description: … In a review of its R&D portfolio, the company announced in August 2005 that it would cease any further …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … In a review of its R&D portfolio, the company announced in August 2005 that it would cease any further …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Sufugolix
Investigational
Matched Iupac: … 1-[4-(5-{[benzyl(methyl)amino]methyl}-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenyl-1H,2H,3H,4H-thieno ... [2,3-d]pyrimidin-6-yl)phenyl]-3-methoxyurea …
SIG-007
SIG-007 is a gene therapy that consists of cells that are genetically modified with a non-viral vector to express human alpha-galactosidase A. Developed by Sigilon Therapeutics, t is being investigated for the treatment of Fabry Disease.
Investigational
Matched Description: … SIG-007 is a gene therapy that consists of cells that are genetically modified with a non-viral vector ... to express human alpha-galactosidase A. …
Cemdisiran
Cemdisiran is under investigation in clinical trial NCT03841448 (A Study of Cemdisiran in Adults With Immunoglobulin a Nephropathy (Igan)).
Investigational
Matched Description: … Immunoglobulin a Nephropathy (Igan)). ... Cemdisiran is under investigation in clinical trial NCT03841448 (A Study of Cemdisiran in Adults With …
Leptazoline C
Leptazoline C is a polar oxazoline from the Cyanobacterium Leptolyngbya sp. Also see Leptazoline A, Leptazoline B, and Leptazoline D.
Experimental
Matched Iupac: … (3R)-3-hydroxy-3-[(4S,5S)-2-(2-hydroxyphenyl)-5-methyl-4,5-dihydro-1,3-oxazol-4-yl]propanoic acid …
Matched Description: … Also see [Leptazoline A], [Leptazoline B], and [Leptazoline D]. ... Leptazoline C is a polar oxazoline from the Cyanobacterium Leptolyngbya sp. …
Matched Description: … Also see [Leptazoline A], [Leptazoline B], and [Leptazoline D]. ... Leptazoline C is a polar oxazoline from the Cyanobacterium Leptolyngbya sp. …
Leptazoline D
Leptazoline D is a polar oxazoline from the Cyanobacterium Leptolyngbya sp. Also see Leptazoline A, Leptazoline B, and Leptazoline C.
Experimental
Matched Iupac: … (2S,3S)-N-(1,3-dihydroxypropan-2-yl)-2,3-dihydroxy-3-[(4S,5S)-2-(2-hydroxyphenyl)-5-methyl-4,5-dihydro …
Matched Description: … Also see [Leptazoline A], [Leptazoline B], and [Leptazoline C]. ... Leptazoline D is a polar oxazoline from the Cyanobacterium Leptolyngbya sp. …
Matched Description: … Also see [Leptazoline A], [Leptazoline B], and [Leptazoline C]. ... Leptazoline D is a polar oxazoline from the Cyanobacterium Leptolyngbya sp. …
Efinopegdutide
Efinopegdutide is under investigation in clinical trial NCT03606057 (A Study to Investigate the Effect of JNJ-64565111 on Cardiac Repolarization (Corrected QT Interval) Compared With Placebo in Healthy Adults: a Thorough ECG Study Employing Placebo, JNJ-64565111, and a Positive Control (Moxifloxacin)).
Investigational
Matched Description: … Thorough ECG Study Employing Placebo, JNJ-64565111, and a Positive Control (Moxifloxacin)). ... Efinopegdutide is under investigation in clinical trial NCT03606057 (A Study to Investigate the Effect ... 64565111 on Cardiac Repolarization (Corrected QT Interval) Compared With Placebo in Healthy Adults: a …
VTX-801
VTX-801 is a replication-deficient recombinant adeno-associated viral vector (rAAV) consisting of an AAV liver tropic capsid containing a single-stranded DNA genome carrying a shortened version of the ATP7B gene (ATP7B-minigene). It is being investigated in Wilson Disease.
Investigational
Matched Description: … AAV liver tropic capsid containing a single-stranded DNA genome carrying a shortened version of the ATP7B ... VTX-801 is a replication-deficient recombinant adeno-associated viral vector (rAAV) consisting of an …
2,6-dicarboxynaphthalene
2,6-dicarboxynaphthalene is a solid. This compound belongs to the naphthalenecarboxylic acids. These are compounds containing a napthalene moiety with a ring carbon which bears a carboxylic acid group. This drug targets the proteins hemoglobin subunit alpha and hemoglobin subunit beta.
Experimental
Matched Description: … These are compounds containing a napthalene moiety with a ring carbon which bears a carboxylic acid group ... 2,6-dicarboxynaphthalene is a solid. This compound belongs to the naphthalenecarboxylic acids. …
MRK-409
MRK-409 is a GABA-A receptor agonist .
Experimental
Matched Iupac: … 5-({[7-cyclobutyl-3-(2,6-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1H …
Matched Description: … MRK-409 is a GABA-A receptor agonist [A31972]. …
Matched Description: … MRK-409 is a GABA-A receptor agonist [A31972]. …
XMT-2056
XMT-2056 is a HER2-targeted antibody-drug conjugate (ADC) consisting of a HER2-targeted antibody conjugated with a stimulator of interferon genes (STING) agonist payload.
Investigational
Matched Description: … XMT-2056 is a HER2-targeted antibody-drug conjugate (ADC) consisting of a HER2-targeted antibody conjugated ... with a stimulator of interferon genes (STING) agonist payload. …
Flurothyl
Flurothyl is a convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.
Withdrawn
Matched Iupac: … 1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane …
Matched Description: … Flurothyl is a convulsant primarily used in experimental animals. ... It was formerly used to induce convulsions as a alternative to electroshock therapy. …
Matched Description: … Flurothyl is a convulsant primarily used in experimental animals. ... It was formerly used to induce convulsions as a alternative to electroshock therapy. …
Furafylline
Furafylline is a derivative of methylxanthine derivative. It was developed on the context of asthma as a long-acting alternative for theophylline.
Experimental
Matched Iupac: … 4-(5-{7-azabicyclo[2.2.1]heptan-2-yl}-2-fluoropyridin-3-yl)benzonitrile …
Matched Description: … Furafylline is a derivative of methylxanthine derivative. ... It was developed on the context of asthma as a long-acting alternative for [theophylline]. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Furafylline is a derivative of methylxanthine derivative. ... It was developed on the context of asthma as a long-acting alternative for [theophylline]. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Dimethylcurcumin
Dimethylcurcumin is a synthetic chemical compound that is loosely based on a compound found in curcumin. It is a novel anti-androgen that enhances androgen receptor degradation.
Investigational
Matched Iupac: … (1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one …
Matched Description: … Dimethylcurcumin is a synthetic chemical compound that is loosely based on a compound found in curcumin ... It is a novel anti-androgen that enhances androgen receptor degradation. …
Matched Description: … Dimethylcurcumin is a synthetic chemical compound that is loosely based on a compound found in curcumin ... It is a novel anti-androgen that enhances androgen receptor degradation. …
Bardoxolone methyl
Investigational
4-[3-carboxymethyl-3-(4-phosphonooxy-benzyl)-ureido]-4-[(3-cyclohexyl-propyl)-methyl-carbamoyl]butyric acid
Experimental
Matched Name: … 4-[3-carboxymethyl-3-(4-phosphonooxy-benzyl)-ureido]-4-[(3-cyclohexyl-propyl)-methyl-carbamoyl]butyric …
Matched Iupac: … (4S)-4-{[(carboxymethyl)({[4-(phosphonooxy)phenyl]methyl})carbamoyl]amino}-4-[(3-cyclohexylpropyl)(methyl …
Matched Iupac: … (4S)-4-{[(carboxymethyl)({[4-(phosphonooxy)phenyl]methyl})carbamoyl]amino}-4-[(3-cyclohexylpropyl)(methyl …
VX-702
VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifically rheumatoid arthritis (RA). It acts as a p38 MAP kinase inhibitor. In the future, VX-702 may be investigated for combination with methotrexate, a commonly used therapy for RA.
Investigational
Matched Iupac: … 2-(2,4-difluorophenyl)-6-[1-(2,6-difluorophenyl)carbamoylamino]pyridine-3-carboxamide …
Matched Description: … It acts as a p38 MAP kinase inhibitor. ... VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases ... In the future, VX-702 may be investigated for combination with methotrexate, a commonly used therapy …
Matched Description: … It acts as a p38 MAP kinase inhibitor. ... VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases ... In the future, VX-702 may be investigated for combination with methotrexate, a commonly used therapy …
Sophora flavescens root
Experimental
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE
Experimental
Matched Name: … 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE …
Matched Iupac: … 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide …
Matched Iupac: … 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide …
Displaying drugs 13126 - 13150 of 13944 in total