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Displaying drugs 1351 - 1375 of 1804 in total

Bendamustine

Bendamustine is a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL). Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine...
Approved
Investigational
Matched Description: … a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and ... Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks ... It is active against both active and quiescent cells, although the exact mechanism of action is unknown …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … BEMUNAT POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/VIAL USP ... BEMUNAT POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/VIAL USP ... RIBOMUSTIN 25MG/VIAL POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION …

Pertuzumab

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. It was first approved by the FDA in...
Approved
Matched Description: … It was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal ... It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. ... Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... pertuzumab and trastuzumab ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … Perjeta 420 mg concentrate for solution for infusion ... PERJETA CONCENTRATE FOR SOLUTION FOR INFUSION 420MG/14ML ... PHESGO SOLUTION FOR SUBCUTANEOUS INJECTION 600 MG/600 MG / 10 ML …

Bevacizumab

There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target for anti-cancer...
Approved
Investigational
Matched Description: … the survival and proliferation of cancer cells. ... [A193272,A193275] It is a humanized monoclonal IgG antibody, and inhibits angiogenesis by binding and ... [A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES ... Experimental Unapproved Treatments for COVID-19 …
Matched Products: … ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/4 ML ... ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 400 MG/16 ML ... MVASI CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/ML …

Mepolizumab

Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm3 or more) is associated with a spectrum of diseases, including severe asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome (HES). The pathogenesis of eosinophilia is complex, but IL-5 is recognized as...
Approved
Investigational
Matched Description: … Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically ... Activated eosinophils further stimulate an inflammatory response and also induce tissue lesions and promote ... Mepolizumab was first approved by the FDA on November 4, 2015, as an add-on therapy for severe asthma …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs for Obstructive Airway Diseases …
Matched Products: … NUCALA POWDER FOR SOLUTION FOR INJECTION 100mg ... Nucala 100mg Powder for Solution for Injection ... NUCALA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML …

(3-Formyl-but-3-Enyl)-Phosphonic Acid

Experimental
Matched Name: … (3-Formyl-but-3-Enyl)-Phosphonic Acid …

5-Formyl-2'-deoxy-cytidine-5'-monophosphate

Experimental
Matched Name: … 5-Formyl-2'-deoxy-cytidine-5'-monophosphate …
Matched Iupac: … {[(2R,3S,5R)-5-(4-amino-5-formyl-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic …

Azacitidine

Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. As an analogue of cytidine, it...
Approved
Investigational
Matched Description: … As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and ... inhibiting protein and DNA synthesis. ... [A1407] Due to its anti-neoplastic activity and its ability to inhibit methylation in replicating DNA …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … Azacitidine For ... Vidaza powder for suspension for injection 100mg/vial ... AZADINE POWDER FOR SUSPENSION FOR INJECTION 100MG/VIAL …

Erenumab

Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines. Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only...
Approved
Investigational
Matched Description: … Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the ... Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and ... first and only FDA approved treatment specifically developed to prevent migraine by blocking the CGRP …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … AIMOVIG (140 MG/ML SOLUTION FOR INJECTION) ... AIMOVIG (70 MG/ML SOLUTION FOR INJECTION) ... AIMOVIG SOLUTION FOR INJECTION IN PRE-FILLED PEN 70MG/ML …

Izokibep

Izokibep is under investigation in clinical trial NCT05623345 (Psoriatic Arthritis Study of Izokibep).
Investigational
Matched Synonyms: … DERIVED FROM THE IMMUNOGLOBULIN (IG)-BINDING Z-DOMAIN OF STAPHYLOCOCCAL PROTEIN A (SPA), ENGINEERED FOR …

Aflibercept

Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … the treatment of retinopathy of prematurity in preterm infants in February 2023 and for the treatment ... and February 2013, respectively. ... the treatment of metastatic colorectal cancer, and it was approved by the FDA and EMA in August 2012 …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Zaltrap 25mg/ml Concentrate for Solution for Infusion ... ZALTRAP CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/ML ... EYLEA SOLUTION FOR INJECTION IN VIAL 2MG …

2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE

Experimental
Matched Name: … 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2- …

Atezolizumab

Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Matched Description: … Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing ... [L7489] In November 2022, the manufacturer (Genentech) voluntarily withdrew the use of atezolizumab for ... [A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 840MG/14ML ... Tecentriq 60mg/ml Concentrate for Solution for Infusion ... TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 1200 MG/ 20 ML …

Alglucosidase alfa

Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. Aglucosidase alfa is produced by recombinant DNA technology in a Chinese hamster ovary cell...
Approved
Matched Description: … It is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients. ... Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages ... residue mature polypeptide chain, and a total mass of approximately 109,000 daltons, including carbohydrates …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Products: … Myozyme Powder for Solution for Injection ... (Alglucosidase alfa) 50mg Powder for Solution for Infusion …

Topotecan

An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … HYCAMTIN (POWDER FOR SOLUTION FOR INFUSION) ... TOCANTIN POWDER FOR SOLUTION FOR INFUSION 4MG ... TOCANTIN POWDER FOR SOLUTION FOR INFUSION 4 MG/VIAL …

Burosumab

Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets . The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Matched Description: … (XLH), which is a rare, inherited form of rickets. ... It causes impaired bone growth and development in children and adolescents and issues with bone mineralization ... This is the first drug approved to treat adults and children ages 1 year and older with X-linked hypophosphatemia …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs Affecting Bone Structure and Mineralization ... Drugs for Treatment of Bone Diseases …
Matched Products: … CRYSVITA 10 MG SOLUTION FOR INJECTION ... CRYSVITA 20 MG SOLUTION FOR INJECTION ... CRYSVITA 30 MG SOLUTION FOR INJECTION …

Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane

Experimental
Matched Name: … Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane …
Matched Iupac: … 5-({[2-({[(2-carboxy-2-methyl-1,3-dioxan-5-yl)oxy]carbonyl}amino)ethyl]carbamoyl}oxy)-2-methyl-1,3-dioxane …

Adalimumab

Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced...
Approved
Experimental
Matched Description: … This drug is available in a prefilled syringe form and convenient pen form for subcutaneous self-administered ... arthritis and other chronic debilitating diseases mediated by tumor necrosis factor. ... [A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Biologics for Rheumatoid Arthritis Treatment …
Matched Products: … IDACIO SOLUTION FOR INJECTION FOR PAEDIATRIC USE 40MG/0.8ML VIAL ... IDACIO solution for Injection for paediatric use 40mg/0.8ml ... HUMIRA SOLUTION FOR INJECTION …

Tirzepatide

Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor agonists in preclinical and clinical trials....
Approved
Investigational
Matched Description: … Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight ... agonists in preclinical and clinical trials. ... Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Mounjaro 2.5 mg solution for injection in pre-filled pen ... Mounjaro 5 mg solution for injection in pre-filled pen ... Mounjaro 7.5 mg solution for injection in pre-filled pen …

Alirocumab

Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and statin treatment. It is a human monoclonal antibody part of the family of the PCSK9 inhibitors which...
Approved
Matched Description: … high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and ... FDA approval was contingent on the completion of further clinical trials to better determine efficacy and ... Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hypolipidemic Agents Indicated for Hyperlipidemia ... Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia …
Matched Products: … PRALUENT 150 MG/ML (SOLUTION FOR INJECTION IN PRE-FILLED PEN) ... PRALUENT 75 MG/ML (SOLUTION FOR INJECTION IN PRE-FILLED PEN) ... PRALUENT SOLUTION FOR INJECTION IN A PRE-FILLED PEN 75MG/ML …

Tozinameran

The Pfizer-BioNTech COVID-19 vaccine (also known as BNT162b2, Tozinameran, and Comirnaty), is one of four advanced mRNA-based vaccines developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002,L15007,L36025] Comirnaty is a nucleoside modified mRNA (modRNA) vaccine encoding an optimized full-length version of the severe acute respiratory syndrome coronavirus 2...
Approved
Investigational
Matched Description: … [L26956] Fact sheets for caregivers, recipients, and healthcare providers are now available. ... Comirnaty is also approved for use as a fourth booster shot in adults 50 years of age and older. ... The Pfizer-BioNTech COVID-19 vaccine (also known as BNT162b2, Tozinameran, and Comirnaty), is one of …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Comirnaty 3mcg Concentrate for Dispersion for Injection ... Comirnaty Omicron XBB.1.5 10 micrograms/dose Dispersion for Injection ... Comirnaty Omicron XBB.1.5 30 micrograms/dose Dispersion for Injection …

Golimumab

Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with...
Approved
Matched Description: … Golimumab binds and inhibits soluble and transmembrane human TNFα. ... Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients ... Additionally in children and adolescents taking golimumab, there have been lymphoma and other malignancies …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Biologics for Rheumatoid Arthritis Treatment …
Matched Products: … Concentrate for Solution for Infusion 12.5mg/1 ml ... SIMPONI IV 12.5mg/1ml Concentrate for Solution for Infusion ... SIMPONI SOLUTION FOR INJECTION …

Pegaspargase

Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagine through the action of asparagine synthetase. However, leukemia...
Approved
Investigational
Matched Description: … Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine ... amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia ... However, leukemia cells have low levels of this enzyme and depend on exogenous sources. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Enzymes and Coenzymes …
Matched Products: … ONCASPAR POWDER FOR SOLUTION FOR INJECTION/INFUSION 750 U/ML ... Oncaspar 750 U/ml powder for solution for injection/infusion …

Doxorubicin

Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.[A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain terminates with a primary alcohol group compared to the methyl group of daunorubicin. Although its detailed...
Approved
Investigational
Matched Synonyms: … MTC-DOX for Injection …
Matched Description: … [A1575,A257709,A257614] Although they both have aglyconic and sugar moieties, doxorubicin's side chain ... Hodgkin’s lymphoma, multiple myeloma, sarcoma, and pediatric cancers. ... generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and …
Matched Categories: … Anthracyclines and Related Substances ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …
Matched Products: … DOXABIN POWDER FOR SOLUTION FOR INJECTION 10MG/VIAL ... DOXABIN POWDER FOR SOLUTION FOR INJECTION 50MG/VIAL ... DOXOCCORD CONCENTRATE FOR SOLUTION FOR INFUSION 2 MG/ML …

Phellodendron amurense bark

Phellodendron amurense bark is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Products: … Jayeonbi Secret Care Mist for Lady Y-zone Mist ... Jayeonbi Secret Care Mist for Men Y-zone Mist ... JAYEONBI Secret Care Mist For Lady Y-zone Mist …

Paclitaxel

Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as...
Approved
Vet approved
Matched Synonyms: … Paclitaxel protein-bound particles for injection suspension …
Matched Description: … It is available as an intravenous solution for injection and the newer formulation contains albumin-bound ... Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... paclitaxel and encequidar …
Matched Products: … Aclipak Concentrate for Solution for Infusion 6mg/ ml ... FONKOPAC CONCENTRATE FOR SOLUTION FOR INFUSION 6MG/ML ... ACLIPAK 6 MG/ ML CONCENTRATE FOR SOLUTION FOR INFUSION …
Displaying drugs 1351 - 1375 of 1804 in total