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Displaying drugs 126 - 136 of 136 in total

Lactulose

Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929 , investigations regarding its possible use as a laxative for...
Approved
Matched Description: … possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and ... [L6202] Nevertheless, although lactulose received formal FDA approval in 1977 and has since become ... List of Essential Medicines as one of the most effective and safe medicines employed in a health system …
Matched Categories: … Alimentary Tract and Metabolism …

Polymyxin B

Polymyxin B was discovered in the 1940s . They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes . Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci,...
Approved
Vet approved
Matched Description: … Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line ... All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant[A176426]. ... Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic …
Matched Mixtures name: … Welly Human Repair Kit ... Water-Jel 3-in-1 Antibiotic ... Neomycin and Polymyxin B Sulfates and Bacitracin Zinc …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Ophthalmological and Otological Preparations …

Tea tree oil

Tea tree oil is an essential oil derived mainly from the Australian native plant Melaleuca alternifolia via steam distillation of the of the leaves and terminal branches . It may be referred to as Melaleuca alternifolia oil. It has been a popular ingredient in a variety of household and cosmetic...
Experimental
Nutraceutical
Matched Synonyms: … Melaleuca alternifolia (tea tree) leaf water …
Matched Description: … , anti-inflammatory, broad-spectrum antimicrobial and antioxidant properties [A32438]. ... from the Australian native plant _Melaleuca alternifolia_ via steam distillation of the of the leaves and ... It has been a popular ingredient in a variety of household and cosmetic products due to its antiseptic …
Matched Mixtures name: … Muscle and Joint Heat Cream ... Bee Venom Wart And Tags Removal Treatment …

Apramycin

Apramycin is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria. Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans.
Experimental
Vet approved
Matched Description: … Apramycin is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria ... Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted …
Matched Products: … APRASUL-100 WATER SOLUBLE POWDER ... TP-APRA 500 WSP ApramycinSulphate 500mg/g Water Soluble Powder …

Queuine

Queuine is a derivative of 7-Deazaguanine. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, and goats. Humans salvage and recover queuine from either...
Experimental
Nutraceutical
Matched Description: … Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, ... and goats. ... plants and animals. …

Alvespimycin

Alvespimycin is a derivative of geldanamycin and heat shock protein (HSP) 90 inhibitor. It has been used in trials studying the treatment of solid tumor in various cancer as an antitumor agent. In comparison to the first HSP90 inhibitor tanespimycin, it exhibits some pharmacologically desirable properties such as reduced metabolic...
Investigational
Matched Description: … pharmacologically desirable properties such as reduced metabolic liability, lower plasma protein binding, increased water ... Alvespimycin is a derivative of geldanamycin and heat shock protein (HSP) 90 inhibitor. ... solubility, higher oral bioavailability, reduced hepatotoxicity and superior antitumor activity [A19243 …

Sennosides

Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label] and empty the large intestine before surgery. The medication is taken by mouth or via the rectum[FDA Label]. It typically begins working in minutes when given by rectum and within twelve hours when given...
Experimental
Matched Description: … laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human ... also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label][L771] and ... It typically begins working in minutes when given by rectum and within twelve hours when given by mouth …
Matched Mixtures name: … Senna and Docusate Sodium ... Senna and Docusate Sodium ... Docusate Sodium and Senna …
Matched Salts name: … Sennosides A and B …
Matched Categories: … Alimentary Tract and Metabolism ... Herbs and Natural Products …

XMT-1001

XMT-1001 is a polymer-based prodrug of camptothecin (CPT), a well-characterized topoisomerase I inhibitor with potent anti-tumor activity. It is a water-soluble macromolecular conjugate of camptothecin (CPT). In this novel CPT pro-drug, CPT is conjugated with a 70 kDa biodegradable hydrophilic polyacetal, poly (1-hydroxymethylene hydroxylmethylformal). XMT-1001 has demonstrated an improved therapeutic...
Investigational
Matched Description: … XMT-1001 has demonstrated an improved therapeutic window as compared with CPT and irinotecan in human ... It is a water-soluble macromolecular conjugate of camptothecin (CPT). …

Rolofylline

Rolofylline is under clinical development by pharmaceutical company NovaCardia for the treatment of congestive heart failure.
Investigational

Ularitide

Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is involved in regulating blood pressure and the excretion of water and sodium from the kidneys. Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally in the...
Investigational
Matched Description: … involved in regulating blood pressure and the excretion of water and sodium from the kidneys. ... Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is ... Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Cannabidivarin

Cannabidivarin, also known as cannabidivarol or CBDV, is a non-psychoactive cannabinoid found within DB14009. It is one of over 100 cannabinoids identified from the Cannabis plant that can modulate the physiological activity of cannabis, or marijuana . Compared to its homolog, DB09061, CBDV is shortened by two methyl (CH2) groups...
Investigational
Matched Description: … Notably, both [DB09061] and CBDV have demonstrated anticonvulsant activity in animal and human models ... CBD and CBDV have been shown to dose-dependently activate and then desensitize TRPV1 as well as TRPV2 ... and TRPA1 channels [A31560, A33334, A32976]. …
Displaying drugs 126 - 136 of 136 in total