Displaying drugs 1576 - 1600 of 1990 in total
ASC-618
ASC-618 is a recombinant adeno-associated virus serotype 8 (rAAV2/8) vector expressing bioengineered B domain deleted liver-codon-optimized human factor VIII.
Investigational
Matched Description: … B domain deleted liver-codon-optimized human factor VIII. ... ASC-618 is a recombinant adeno-associated virus serotype 8 (rAAV2/8) vector expressing bioengineered …
GI-101
GI-101 is a bi-specific fragment crystallizable region (Fc) fusion protein containing a cluster of differentiation 80 ectodomain as an N-terminal moiety and interleukin-2 variant as a C-terminal moiety conjugated with human immunoglobulin G4 Fc.
Investigational
Matched Description: … interleukin-2 variant as a C-terminal moiety conjugated with human immunoglobulin G4 Fc. ... region (Fc) fusion protein containing a cluster of differentiation 80 ectodomain as an N-terminal moiety and …
GSK-923295
GSK-923295 is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), and the third novel drug candidate to arise from Cytokinetics' broad strategic alliance with GlaxoSmithKline (GSK). GSK-923295 demonstrated a broad spectrum of activity against a range of human tumor xenografts grown in nude mice, including models of...
Investigational
Matched Description: … and is currently in Phase I human clinical trials being conducted by GSK. ... in nude mice, including models of colon, breast, ovarian, lung and other tumors. ... 923295 is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), and …
FLT201
FLT201 is a recombinant adeno-associated viral vector serotype S3 containing codon optimised expression cassette encoding human beta (β)-glucocerebrosidase variant 85 (GCasevar85)
Investigational
Matched Description: … cassette encoding human beta (β)-glucocerebrosidase variant 85 (GCasevar85) ... FLT201 is a recombinant adeno-associated viral vector serotype S3 containing codon optimised expression …
Vilobelimab
Vilobelimab is a chimeric monoclonal immunoglobulin G4 (IgG4) antibody that binds to the soluble form of human C5a with high affinity. It consists of mouse anti-human complement factor 5a (C5a) monoclonal binding sites (variable regions of heavy and light chain regions) and human gamma 4 heavy chain and light kappa...
Investigational
Matched Description: … of heavy and light chain regions) and human gamma 4 heavy chain and light kappa chain constant regions ... Vilobelimab is a chimeric monoclonal immunoglobulin G4 (IgG4) antibody that binds to the soluble form ... of human C5a with high affinity. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
AVP-21D9
AVP-21D9 is a fully human anthrax monoclonal antibody that is being investigated as an anthrax antitoxin.
Investigational
Matched Description: … AVP-21D9 is a fully human anthrax monoclonal antibody that is being investigated as an anthrax antitoxin …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
GLPG-0492
Glpg0492 is under investigation in clinical trial NCT01130818 (First-in-Human Single Ascending Dose of GLPG0492).
Investigational
Matched Description: … Glpg0492 is under investigation in clinical trial NCT01130818 (First-in-Human Single Ascending Dose of …
N4-Hydroxycytidine
N4-Hydroxyctidine, or EIDD-1931, is a ribonucleoside analog which induces mutations in RNA virions.[A193008,A193011] N4-hydroxycytidine was first described in the literature in 1980 as a potent mutagen of bacteria and phage. It has shown antiviral activity against Venezuelan equine encephalitis virus, and the human coronavirus HCoV-NL63 in vitro. N4-hydroxycytodine has been...
Experimental
Matched Description: … in mice and human airway epithelial cells. ... [A193017] N4-hydroxycytodine has been shown to inhibit SARS-CoV-2 as well as other human and bat coronaviruses ... the human coronavirus HCoV-NL63 _in vitro_. …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
ATP
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Investigational
Nutraceutical
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
PBGM01
PBGM01 is a non-replicating recombinant adeno-associated virus serotype hu68 vector, which contains human GLB1 transgene encoding the galactosidase beta 1 enzyme.
Investigational
Matched Description: … PBGM01 is a non-replicating recombinant adeno-associated virus serotype hu68 vector, which contains human …
Iboctadekin
Iboctadekin is under investigation in clinical trial NCT00500058 (A Phase I, Dose-Escalation Study to Assess the Safety and Biological Activity of Recombinant Human Interleukin-18).
Investigational
Matched Description: … Biological Activity of Recombinant Human Interleukin-18). ... investigation in clinical trial NCT00500058 (A Phase I, Dose-Escalation Study to Assess the Safety and …
TAK-611
TAK-611, formerly known as SHP611, is a recombinant human arylsulfatase A. First developed by Takeda, it is being investigated for the treatment of metachromatic leukodystrophy.
Investigational
Matched Description: … TAK-611, formerly known as SHP611, is a recombinant human arylsulfatase A. …
Hu-rhEGF-rP64k/Mont
Hu-rhEGF-rP64k/Mont is a therapeutic vaccine composed by an antigen (recombinant human EGF (rhEGF) chemically conjugated to recombinant P64K (rP64K)) and an adjuvant (Montanide ISA51VG) being investigated for the treatment of advanced non-small cell lung cancer (NSCLC).
Investigational
Matched Description: … Hu-rhEGF-rP64k/Mont is a therapeutic vaccine composed by an antigen (recombinant human EGF (rhEGF) chemically ... conjugated to recombinant P64K (rP64K)) and an adjuvant (Montanide ISA51VG) being investigated for the …
GSK-364735
GSK-364735 (Naphthyridinone) has been used in trials studying the treatment of HIV-1 Infection and Infection, Human Immunodeficiency Virus.
Investigational
Matched Description: … , Human Immunodeficiency Virus. ... GSK-364735 (Naphthyridinone) has been used in trials studying the treatment of HIV-1 Infection and Infection …
Epafipase
Epafipase is under investigation in clinical trial NCT00037687 (Safety and Efficacy of Recombinant Human Platelet-activating Factor Acetylhydrolase for the Treatment of Severe Sepsis).
Investigational
Matched Description: … Epafipase is under investigation in clinical trial NCT00037687 (Safety and Efficacy of Recombinant Human …
Interferon alfa
Natural interferon alpha or Multiferon is obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography. Interferon alpha proteins are mainly involved in innate immune response against viral infection. They come in 13...
Investigational
Matched Description: … Natural interferon alpha or Multiferon is obtained from the leukocyte fraction of human blood following ... Of these, IFN-α2 and IFN-α14 are glycosylated. ... Multiferon consists of the 6 major subtypes are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Onercept
Investigational
Matched Categories: … Recombinant Proteins ... Amino Acids, Peptides, and Proteins …
Gentulizumab
Investigational
GS-100
GS-100 is an adeno-associated virus serotype 9 virus particle containing viral DNA that includes an expression cassette containing the human NGLY1 gene coding sequence
Investigational
Matched Description: … serotype 9 virus particle containing viral DNA that includes an expression cassette containing the human …
Clenoliximab
Clenoliximab is a chimeric monoclonal antibody from Macaca irus against CD4 which acts as an immunomodulator. It has investigated for the treatment of rheumatoid arthritis.
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins …
Grn163l
GRN163L is a novel anti-cancer drug. It has been characterized preclinically and shown to inhibit telomerase in human tumor cells of many cancer types (including lung, breast, prostate, liver, and early stage of human breast cancer), in both cell culture systems and animal models. Study of this drug shows the...
Investigational
Matched Description: … It has been characterized preclinically and shown to inhibit telomerase in human tumor cells of many ... cancer types (including lung, breast, prostate, liver, and early stage of human breast cancer), in both ... cell culture systems and animal models. …
Icotinib
Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)
Icotinib was approved in China by the SFDA in June, 2011 and in January 2014, Beta Pharma, Inc. was given a “May Proceed” from the US FDA to conduct a Phase I study for the...
Experimental
Investigational
Matched Iupac: … N-(3-ethynylphenyl)-7H,8H,10H,11H,13H,14H-1,4,7,10-tetraoxacyclododeca[2,3-g]quinazolin-4-amine …
Matched Description: … Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ( ... TKI) Icotinib was approved in China by the SFDA in June, 2011 and in January 2014, Beta Pharma, Inc. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ( ... TKI) Icotinib was approved in China by the SFDA in June, 2011 and in January 2014, Beta Pharma, Inc. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
HMI-203
HMI-203 is an investigational gene therapy developed by Homology Medicines, Inc. It consists of a recombinant adeno-associated virus (AAV) serotype HSC15 (rAAVHSC15) encoding human iduronate-2-sulfatase (hIDS).
Investigational
Matched Description: … It consists of a recombinant adeno-associated virus (AAV) serotype HSC15 (rAAVHSC15) encoding human iduronate …
Gam-COVID-Vac
Gam-COVID-Vac was created by Gamaleya Research Institute of Epidemiology and MIcrobiology in Russia. The vaccine candidate is a heterologous COVID-19 vaccine containing two components, recombinant adenovirus type 26 (rAd26) vector and recombinant adenovirus type 5 (rAd5) vector which both carry the SARS-CoV-2 spike glycoprotein. The vaccine is offered in both...
Investigational
Matched Description: … Phase 1/2 human trials with 76 participants evaluated the safety, tolerability, and immunogenicity of ... type 26 (rAd26) vector and recombinant adenovirus type 5 (rAd5) vector which both carry the SARS-CoV ... The vaccine candidate is a heterologous COVID-19 vaccine containing two components, recombinant adenovirus …
MW33
MW33 is a recombinant fully human antibody to SARS-CoV-2. This antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A Clinical Study to Evaluate MW33 Injection).
Investigational
Matched Description: … MW33 is a recombinant fully human antibody to SARS-CoV-2. …
Displaying drugs 1576 - 1600 of 1990 in total