Displaying drugs 2401 - 2425 of 2845 in total
Ceritinib
Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Synonyms: … -{2-[(5-chloro-2-{[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propane …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like 4) and ... lymphoma kinase), which results in constitutive kinase activity that contributes to carcinogenesis and ... autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Tyrosine Kinase Inhibitors ... ROS1 tyrosine kinase inhibitors ... Receptor Protein-Tyrosine Kinases, antagonists & inhibitors …
Matched Iupac: … 5-chloro-N2-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine …
Matched Description: … rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like 4) and ... lymphoma kinase), which results in constitutive kinase activity that contributes to carcinogenesis and ... autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Tyrosine Kinase Inhibitors ... ROS1 tyrosine kinase inhibitors ... Receptor Protein-Tyrosine Kinases, antagonists & inhibitors …
Isoliquiritigenin
Isoliquiritigenin is a precursor to several flavonones in many plants.
Experimental
Matched Synonyms: … (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one …
3-[N-[benzyloxycarbonyl]-phenylalaninyl-amino]-5-phenyl-pentane-1-sulfonylmethylbenzene
Experimental
Matched Name: … 3-[N-[benzyloxycarbonyl]-phenylalaninyl-amino]-5-phenyl-pentane-1-sulfonylmethylbenzene …
Diaziquone
Investigational
Matched Synonyms: … Carbamic acid, (2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl)bis-, diethyl ester …
Matched Categories: … Indicators and Reagents …
Matched Categories: … Indicators and Reagents …
TAK-603
Investigational
Matched Synonyms: … 3-quinolinecarboxylic acid, 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1h-1,2,4-triazol-1-ylmethyl)-, ethyl …
(3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine
Experimental
Matched Name: … (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine …
Matched Iupac: … (3,4-dihydroxyphenyl)acetyl]oxy}-2-[(2-formylindolizin-3-yl)amino]-3-methyl-3-[(S)-sulfino]butanoic acid …
Matched Iupac: … (3,4-dihydroxyphenyl)acetyl]oxy}-2-[(2-formylindolizin-3-yl)amino]-3-methyl-3-[(S)-sulfino]butanoic acid …
Sulanemadlin
Investigational
Matched Synonyms: … N-acetyl-l-leucyl-l-threonyl-l-phenylalanyl-cyclo(d-r8-l-glutamyl-ltyrosyl-ltryptophanyl-l-alanyl-l-glutaminyl-l-leucyl-l-s5 …
L-gamma-glutamyl-S-(naphthalen-1-ylmethyl)-L-cysteinylglycine
Experimental
Matched Name: … L-gamma-glutamyl-S-(naphthalen-1-ylmethyl)-L-cysteinylglycine …
Matched Iupac: … 4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-{[(naphthalen-1-yl)methyl]sulfanyl}ethyl]carbamoyl}butanoic acid …
Matched Iupac: … 4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-{[(naphthalen-1-yl)methyl]sulfanyl}ethyl]carbamoyl}butanoic acid …
N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Experimental
Matched Name: … N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE …
Matched Iupac: … 3S)-2-{[(2S,3S)-3-(benzylcarbamoyl)oxiran-2-yl]formamido}-3-methylpentanoyl]pyrrolidine-2-carboxylic acid …
Matched Iupac: … 3S)-2-{[(2S,3S)-3-(benzylcarbamoyl)oxiran-2-yl]formamido}-3-methylpentanoyl]pyrrolidine-2-carboxylic acid …
Simvastatin
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production...
Approved
Matched Synonyms: … 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy …
Matched Description: … hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid ... belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and ... referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). …
Matched Mixtures name: … Ezetimibe and Simvastatin ... Ezetimibe and Simvastatin ... Ezetimibe and Simvastatin …
Matched Categories: … simvastatin and acetylsalicylic acid ... simvastatin, acetylsalicylic acid and ramipril ... simvastatin and ezetimibe ... sitagliptin and simvastatin ... simvastatin and fenofibrate …
Matched Description: … hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid ... belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and ... referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). …
Matched Mixtures name: … Ezetimibe and Simvastatin ... Ezetimibe and Simvastatin ... Ezetimibe and Simvastatin …
Matched Categories: … simvastatin and acetylsalicylic acid ... simvastatin, acetylsalicylic acid and ramipril ... simvastatin and ezetimibe ... sitagliptin and simvastatin ... simvastatin and fenofibrate …
2-amino-3-(4-amino-1H-indol-3-yl)propanoic acid
Experimental
Matched Name: … 2-amino-3-(4-amino-1H-indol-3-yl)propanoic acid …
Matched Iupac: … (2S)-2-amino-3-(4-amino-1H-indol-3-yl)propanoic acid …
Matched Iupac: … (2S)-2-amino-3-(4-amino-1H-indol-3-yl)propanoic acid …
Adamantane-1-Carboxylic Acid-5-Dimethylamino-Naphthalene-1-Sulfonylamino-Butyl-Amide
Experimental
Matched Name: … Adamantane-1-Carboxylic Acid-5-Dimethylamino-Naphthalene-1-Sulfonylamino-Butyl-Amide …
Adenosine Diphosphate 5-(Beta-Ethyl)-4-Methyl-Thiazole-2-Carboxylic Acid
Experimental
Matched Name: … Adenosine Diphosphate 5-(Beta-Ethyl)-4-Methyl-Thiazole-2-Carboxylic Acid …
2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID
Experimental
Matched Name: … 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID …
Matched Iupac: … 2-{[7-(carboxymethoxy)-9-(hydroxyimino)-9H-fluoren-2-yl]oxy}acetic acid …
Matched Iupac: … 2-{[7-(carboxymethoxy)-9-(hydroxyimino)-9H-fluoren-2-yl]oxy}acetic acid …
(2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid
Experimental
Matched Name: … (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid …
Matched Iupac: … (2S)-2-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}butanoic acid …
Matched Iupac: … (2S)-2-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}butanoic acid …
(2S)-2-(3-Carbamimidamidophenyl)-3-[hydroxy(3-phenylpropyl)phosphoryl]propanoic acid
Experimental
Matched Name: … (2S)-2-(3-Carbamimidamidophenyl)-3-[hydroxy(3-phenylpropyl)phosphoryl]propanoic acid …
Matched Iupac: … 2-{3-[(diaminomethylidene)amino]phenyl}-3-[hydroxy(3-phenylpropyl)phosphoryl]propanoic acid …
Matched Iupac: … 2-{3-[(diaminomethylidene)amino]phenyl}-3-[hydroxy(3-phenylpropyl)phosphoryl]propanoic acid …
4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID
Experimental
Matched Name: … 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID …
Matched Iupac: … 4-bromo-3-(carboxymethoxy)-5-(4-hydroxyphenyl)thiophene-2-carboxylic acid …
Matched Iupac: … 4-bromo-3-(carboxymethoxy)-5-(4-hydroxyphenyl)thiophene-2-carboxylic acid …
3,4-DI-1H-INDOL-3-YL-1H-PYRROLE-2,5-DICARBOXYLIC ACID
Experimental
Matched Name: … 3,4-DI-1H-INDOL-3-YL-1H-PYRROLE-2,5-DICARBOXYLIC ACID …
Matched Iupac: … 3,4-bis(1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid …
Matched Iupac: … 3,4-bis(1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid …
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID
Experimental
Matched Name: … 1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID …
Matched Iupac: … 1-(3,5-dichlorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxylic acid …
Matched Iupac: … 1-(3,5-dichlorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxylic acid …
(RP,SP)-O-(2R)-(1-PHENOXYBUT-2-YL)-METHYLPHOSPHONIC ACID CHLORIDE
Experimental
Matched Name: … (RP,SP)-O-(2R)-(1-PHENOXYBUT-2-YL)-METHYLPHOSPHONIC ACID CHLORIDE …
2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID
Experimental
Matched Name: … 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID …
Matched Iupac: … 2-(4-{[(3,5-dichlorophenyl)carbamoyl]amino}phenoxy)-2-methylpropanoic acid …
Matched Iupac: … 2-(4-{[(3,5-dichlorophenyl)carbamoyl]amino}phenoxy)-2-methylpropanoic acid …
3-OXO-OCTANOIC ACID (2-OXO-TETRAHYDRO-FURAN-3-YL)-AMIDE
Experimental
Matched Name: … 3-OXO-OCTANOIC ACID (2-OXO-TETRAHYDRO-FURAN-3-YL)-AMIDE …
3-(5-Amino-3-imino-3H-pyrazol-4-ylazo)-benzoic acid
3-(5-amino-3-imino-3H-pyrazol-4-ylazo)-benzoic acid is a solid. This compound belongs to the aminobenzoic acid derivatives. These are benzoic acids (or derivatives thereof) containing an amine group attached to the benzene moiety. 3-(5-amino-3-imino-3H-pyrazol-4-ylazo)-benzoic acid targets the protein methionine aminopeptidase.
Experimental
Matched Name: … 3-(5-Amino-3-imino-3H-pyrazol-4-ylazo)-benzoic acid …
Matched Iupac: … 3-[2-(3,5-diimino-4,5-dihydro-3H-pyrazol-4-ylidene)hydrazin-1-yl]benzoic acid …
Matched Description: … . 3-(5-amino-3-imino-3H-pyrazol-4-ylazo)-benzoic acid targets the protein methionine aminopeptidase. ... 3-(5-amino-3-imino-3H-pyrazol-4-ylazo)-benzoic acid is a solid. ... This compound belongs to the aminobenzoic acid derivatives. …
Matched Iupac: … 3-[2-(3,5-diimino-4,5-dihydro-3H-pyrazol-4-ylidene)hydrazin-1-yl]benzoic acid …
Matched Description: … . 3-(5-amino-3-imino-3H-pyrazol-4-ylazo)-benzoic acid targets the protein methionine aminopeptidase. ... 3-(5-amino-3-imino-3H-pyrazol-4-ylazo)-benzoic acid is a solid. ... This compound belongs to the aminobenzoic acid derivatives. …
Sodium citrate
Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water,
practically insoluble in alcohol. Like citric acid, it has a sour taste.
From the medical point of view, it is used as alkalinizing...
Approved
Investigational
Matched Synonyms: … Citric acid, trisodium salt …
Matched Description: … It works by neutralizing excess acid in the blood and urine. ... Sodium citrate is the sodium salt of citric acid. ... Like citric acid, it has a sour taste. …
Matched Mixtures name: … Sodium Citrate and Citric Acid ... Sodium Citrate and Citric Acid ... Sodium Citrate and Citric Acid …
Matched Categories: … Antacids and Adsorbents ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Diet, Food, and Nutrition ... Acids, Acyclic …
Matched Description: … It works by neutralizing excess acid in the blood and urine. ... Sodium citrate is the sodium salt of citric acid. ... Like citric acid, it has a sour taste. …
Matched Mixtures name: … Sodium Citrate and Citric Acid ... Sodium Citrate and Citric Acid ... Sodium Citrate and Citric Acid …
Matched Categories: … Antacids and Adsorbents ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Diet, Food, and Nutrition ... Acids, Acyclic …
Rifampin
Rifampin, also known as rifampicin, is a broad-spectrum antimicrobial that was first discovered in 1965 and clinically used in 1968. Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent RNA polymerase (RNAP).
Approved
Matched Synonyms: … piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate …
Matched Iupac: … -8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate …
Matched Description: … rifampicin, is a broad-spectrum antimicrobial [A263748] that was first discovered in 1965 [A263753] and ... [A263768] Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... dapsone and rifampicin ... rifampicin and isoniazid ... dapsone, rifampicin and clofazimine ... rifampicin, ethambutol and isoniazid …
Matched Iupac: … -8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate …
Matched Description: … rifampicin, is a broad-spectrum antimicrobial [A263748] that was first discovered in 1965 [A263753] and ... [A263768] Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... dapsone and rifampicin ... rifampicin and isoniazid ... dapsone, rifampicin and clofazimine ... rifampicin, ethambutol and isoniazid …
Displaying drugs 2401 - 2425 of 2845 in total