Signal transduction via the stem cell factor receptor/c-Kit.

Article Details


Ronnstrand L

Signal transduction via the stem cell factor receptor/c-Kit.

Cell Mol Life Sci. 2004 Oct;61(19-20):2535-48. doi: 10.1007/s00018-004-4189-6.

PubMed ID
15526160 [ View in PubMed

Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors. Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will thereby be recruited to the receptor and activated many times through phosphorylation by the receptor. This review discusses our current knowledge of signal transduction molecules and signal transduction pathways activated by c-Kit and how their activation can be connected to the physiological outcome of c-Kit signaling.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AncestimMast/stem cell growth factor receptor KitProteinHumans
NameUniProt ID
RAC-alpha serine/threonine-protein kinaseP31749Details
Mast/stem cell growth factor receptor KitP10721Details
Signal transducer and activator of transcription 5BP51692Details
Growth factor receptor-bound protein 2P62993Details
Mitogen-activated protein kinase 1P28482Details
Phosphatidylinositol 3-kinase regulatory subunit alphaP27986Details
Mitogen-activated protein kinase 3P27361Details
Tyrosine-protein phosphatase non-receptor type 11Q06124Details
Protein kinase C alpha typeP17252Details
Signal transducer and activator of transcription 3P40763Details
Tyrosine-protein phosphatase non-receptor type 6P29350Details
Signal transducer and activator of transcription 1-alpha/betaP42224Details