Signal transduction via the stem cell factor receptor/c-Kit.
Article Details
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Ronnstrand L
Signal transduction via the stem cell factor receptor/c-Kit.
Cell Mol Life Sci. 2004 Oct;61(19-20):2535-48. doi: 10.1007/s00018-004-4189-6.
- PubMed ID
- 15526160 [ View in PubMed]
- Abstract
Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors. Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will thereby be recruited to the receptor and activated many times through phosphorylation by the receptor. This review discusses our current knowledge of signal transduction molecules and signal transduction pathways activated by c-Kit and how their activation can be connected to the physiological outcome of c-Kit signaling.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ancestim Mast/stem cell growth factor receptor Kit Protein Humans YesAgonistDetails - Polypeptides
Name UniProt ID RAC-alpha serine/threonine-protein kinase P31749 Details Mast/stem cell growth factor receptor Kit P10721 Details Signal transducer and activator of transcription 5B P51692 Details Growth factor receptor-bound protein 2 P62993 Details Mitogen-activated protein kinase 1 P28482 Details Phosphatidylinositol 3-kinase regulatory subunit alpha P27986 Details Mitogen-activated protein kinase 3 P27361 Details Tyrosine-protein phosphatase non-receptor type 11 Q06124 Details Protein kinase C alpha type P17252 Details Signal transducer and activator of transcription 3 P40763 Details Tyrosine-protein phosphatase non-receptor type 6 P29350 Details Signal transducer and activator of transcription 1-alpha/beta P42224 Details