The structural biology of oestrogen metabolism.

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Thomas MP, Potter BV

The structural biology of oestrogen metabolism.

J Steroid Biochem Mol Biol. 2013 Sep;137:27-49. doi: 10.1016/j.jsbmb.2012.12.014. Epub 2013 Jan 4.

PubMed ID

23291110 [ View in PubMed

]

Abstract

Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product. The reactions catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation. The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures. This review looks at each of these enzymes in turn, describing the structure and discussing the mechanism of the catalysed reaction. Since oestrogen has a role in many disease states inhibition of the enzymes of oestrogen metabolism may have an impact on the state or progression of the disease and inhibitors of these enzymes are briefly discussed. This article is part of a Special Issue entitled 'CSR 2013'.

DrugBank Data that Cites this Article

Drugs

Estetrol

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Estrone	Cytochrome P450 1B1	Protein	Humans	Unknown	Substrate	Details

Drug Interactions

Drugs	Interaction
Integrate drug-drug interactions in your software
Diethylstilbestrol Butabarbital	The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Butabarbital.
Estetrol Butabarbital	The therapeutic efficacy of Estetrol can be decreased when used in combination with Butabarbital.
Estradiol Butabarbital	The therapeutic efficacy of Estradiol can be decreased when used in combination with Butabarbital.
Estradiol cypionate Butabarbital	The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Butabarbital.
Estradiol valerate Butabarbital	The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Butabarbital.