Coagulation factor VIII

BE0000016ProteinHumansF8

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. It is acted on by 31 drugs in DrugBank.

Gene name
F8
UniProtKB entry
P00451Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
2,351 residues · 267,007 Da
Also known as
AHF · Antihemophilic factor · F8C · Procoagulant component

Resolves to

Protein
UniProtP00451UniProt nameFA8_HUMAN
Gene
HGNCHGNC:3546NCBI Gene2157GenBank182818GeneCardsF8
Pharmacology
KEGGhsa:2157
Structure
PDB1CFGPDB1D7PPDB1FAC
Drugs

What you can answer from here — as of September 07, 2019

31DrugsApproved to experimental, with action, bond type and pharmacological action
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46Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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166+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Coagulation factor VIII, how selective are they, and which programs against it are still in active trials?

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