Cystine/glutamate transporter

BE0000030ProteinHumansSLC7A11

Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:11133847, PubMed:11417227, PubMed:14722095, PubMed:15151999, PubMed:34880232, PubMed:35245456, PubMed:35352032). It is acted on by 12 drugs in DrugBank.

Gene name
SLC7A11
UniProtKB entry
Q9UPY5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
501 residues · 55,422 Da
Also known as
Amino acid transport system xc- · Calcium channel blocker resistance protein CCBR1 · Solute carrier family 7 member 11 · xCT

Resolves to

Protein
UniProtQ9UPY5UniProt nameXCT_HUMAN
Gene
HGNCHGNC:11059NCBI Gene23657GenBank5668545GeneCardsSLC7A11
Pharmacology
IUPHAR/GtoPdb902KEGGhsa:23657
Structure
PDB7CCSPDB7EPZPDB7P9U
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cystine/glutamate transporter, how selective are they, and which programs against it are still in active trials?

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