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Naporafenib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Data Packages
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Identification

Generic Name
Naporafenib
DrugBank Accession Number
DB18865
Background

Naporafenib is under investigation in clinical trial NCT06346067 (A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With Nras-mutant Melanoma (SEACRAFT-2)).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 502.494
Monoisotopic: 502.18278979
Chemical Formula
C25H25F3N4O4
Synonyms
  • 4-pyridinecarboxamide, n-(3-(2-(2-hydroxyethoxy)-6-(4-morpholinyl)-4-pyridinyl)-4-methylphenyl)-2-(trifluoromethyl)-)-
  • N-(3-(2-(hydroxyethoxy)-6-(morpholin-4-yl) pyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)pyridine-4-carboxamide
  • Pan-raf inhibitor lxh254
External IDs
  • LXH 254
  • LXH-254
  • LXH254
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
15JL80DG6H
CAS number
1800398-38-2
InChI Key
UEPXBTCUIIGYCY-UHFFFAOYSA-N
InChI
InChI=1S/C25H25F3N4O4/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33/h2-5,12-15,33H,6-11H2,1H3,(H,30,34)
IUPAC Name
SMILES
CC1=CC=C(NC(=O)C2=CC=NC(=C2)C(F)(F)F)C=C1C1=CC(OCCO)=NC(=C1)N1CCOCC1

References

General References
Not Available
ChemSpider
67886371
BindingDB
88120
ChEMBL
CHEMBL4583691
PDBe Ligand
K81

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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3RecruitingTreatmentAdvanced or Metastatic NRAS-mutant Melanoma1somestatusstop reasonjust information to hide
2Active Not RecruitingTreatmentMelanoma1somestatusstop reasonjust information to hide
1Active Not RecruitingTreatmentBRAF V600 Colorectal Cancer1somestatusstop reasonjust information to hide
1Active Not RecruitingTreatmentEGFR Positive Non-small Cell Lung Cancer1somestatusstop reasonjust information to hide
1RecruitingTreatmentAdvanced or Metastatic Solid Tumor1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 26, 2024 20:28 / Updated at June 27, 2024 01:29