Sterol O-acyltransferase 1

BE0000105ProteinHumansSOAT1

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). It is acted on by 10 drugs in DrugBank.

Gene name
SOAT1
UniProtKB entry
P35610Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
550 residues · 64,734 Da
Also known as
2.3.1.26 · ACACT · ACACT1 · ACAT · ACAT-1

Resolves to

Protein
UniProtP35610UniProt nameSOAT1_HUMAN
Gene
HGNCHGNC:11177NCBI Gene6646GenBank4878022GeneCardsSOAT1
Pharmacology
KEGGhsa:6646
Structure
PDB6L47PDB6L48PDB6P2J
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
14GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
34+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Sterol O-acyltransferase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In