Gonadotropin-releasing hormone receptor

BE0000203ProteinHumansGNRHR

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It is acted on by 27 drugs in DrugBank.

Gene name
GNRHR
UniProtKB entry
P30968Swiss-Prot
Cellular location
Cell membrane
Residues / weight
328 residues · 37,730 Da
Also known as
GnRH receptor · GnRH-R · GRHR

Resolves to

Protein
UniProtP30968UniProt nameGNRHR_HUMAN
Gene
HGNCHGNC:4421NCBI Gene2798GenBank183422GeneCardsGNRHR
Pharmacology
IUPHAR/GtoPdb256KEGGhsa:2798
Structure
PDB7BR3
Drugs

What you can answer from here — as of September 07, 2019

27DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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139+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gonadotropin-releasing hormone receptor, how selective are they, and which programs against it are still in active trials?

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