Ribosyldihydronicotinamide dehydrogenase [quinone]

BE0000220ProteinHumansNQO2

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in... It is acted on by 20 drugs in DrugBank.

Gene name
NQO2
UniProtKB entry
P16083Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
231 residues · 25,918 Da
Also known as
1.10.5.1 · NMOR2 · NRH dehydrogenase [quinone] 2 · NRH:quinone oxidoreductase 2 · QR2

Resolves to

Protein
UniProtP16083UniProt nameNQO2_HUMAN
Gene
HGNCHGNC:7856NCBI Gene4835GenBank190818GeneCardsNQO2
Pharmacology
KEGGhsa:4835
Structure
PDB1QR2PDB1SG0PDB1XI2
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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62+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ribosyldihydronicotinamide dehydrogenase [quinone], how selective are they, and which programs against it are still in active trials?

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