Sodium/potassium-transporting ATPase subunit gamma

Details

Name

Sodium/potassium-transporting ATPase subunit gamma

Kind

protein

Synonyms

• ATP1C
• ATP1G1
• FXYD domain-containing ion transport regulator 2
• Na(+)/K(+) ATPase subunit gamma
• Sodium pump gamma chain

Gene Name

FXYD2

UniProtKB Entry

P54710Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0000457|Sodium/potassium-transporting ATPase subunit gamma
MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQ
INEDEP

Number of residues

66

Molecular Weight

7283.265

Theoretical pI

8.47

GO Classification

Functions

sodium channel regulator activity

Processes

establishment or maintenance of transmembrane electrochemical gradient / potassium ion import across plasma membrane / transmembrane transport

Components

extracellular exosome / plasma membrane / sodium

General Function

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase

Specific Function

Atpase activator activity

Pfam Domain Function

• ATP1G1_PLM_MAT8 (PF02038)

Signal Regions

Not Available

Transmembrane Regions

29-46

Cellular Location

Membrane

Gene sequence

>lcl|BSEQ0010020|Sodium/potassium-transporting ATPase subunit gamma (FXYD2)
ATGACTGGGTTGTCGATGGACGGTGGCGGCAGCCCCAAGGGGGACGTGGACCCGTTCTAC
TATGACTATGAGACCGTTCGCAATGGGGGCCTGATCTTCGCTGGACTGGCCTTCATCGTG
GGGCTCCTCATCCTCCTCAGCAGAAGATTCCGCTGTGGGGGCAATAAGAAGCGCAGGCAA
ATCAATGAAGATGAGCCGTAA

Chromosome Location

11

Locus

11q23.3

External Identifiers

Resource	Link
UniProtKB ID	P54710
UniProtKB Entry Name	ATNG_HUMAN
GenBank Protein ID	1575004
GenBank Gene ID	U50743
GeneCard ID	FXYD2
GenAtlas ID	FXYD2
HGNC ID	HGNC:4026
PDB ID(s)	2MKV, 7E1Z, 7E20, 7E21
KEGG ID	hsa:486
NCBI Gene ID	486

General References

1. Kim JW, Lee Y, Lee IA, Kang HB, Choe YK, Choe IS: Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma-subunit. Biochim Biophys Acta. 1997 Feb 7;1350(2):133-5. [Article]
2. Sweadner KJ, Wetzel RK, Arystarkhova E: Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase. Biochem Biophys Res Commun. 2000 Dec 9;279(1):196-201. [Article]
3. Meij IC, Koenderink JB, van Bokhoven H, Assink KF, Groenestege WT, de Pont JJ, Bindels RJ, Monnens LA, van den Heuvel LP, Knoers NV: Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit. Nat Genet. 2000 Nov;26(3):265-6. [Article]
4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Cyclothiazide	approved	yes	target	inhibitor	Details
Thimerosal	approved	unknown	target	antagonist	Details
Potassium gluconate	approved	no	enzyme	substrateinducer	Details
Rubidium Rb-82	approved, investigational	no	transporter	substrate	Details