Sodium/potassium-transporting ATPase subunit gamma

Details

Name
Sodium/potassium-transporting ATPase subunit gamma
Synonyms
  • ATP1C
  • ATP1G1
  • FXYD domain-containing ion transport regulator 2
  • Na(+)/K(+) ATPase subunit gamma
  • Sodium pump gamma chain
Gene Name
FXYD2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000457|Sodium/potassium-transporting ATPase subunit gamma
MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQ
INEDEP
Number of residues
66
Molecular Weight
7283.265
Theoretical pI
8.47
GO Classification
Functions
ion channel activity / sodium / sodium channel regulator activity / transporter activity
Processes
ATP hydrolysis coupled transmembrane transport / establishment or maintenance of transmembrane electrochemical gradient / ion transmembrane transport / potassium ion import across plasma membrane / regulation of cell growth / regulation of cell proliferation / regulation of sodium ion transmembrane transporter activity / sodium ion export from cell / transmembrane transport / transport
Components
basolateral plasma membrane / extracellular exosome / integral component of plasma membrane / intracellular membrane-bounded organelle / plasma membrane / sodium
General Function
Transporter activity
Specific Function
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Pfam Domain Function
Transmembrane Regions
29-46
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0010020|Sodium/potassium-transporting ATPase subunit gamma (FXYD2)
ATGACTGGGTTGTCGATGGACGGTGGCGGCAGCCCCAAGGGGGACGTGGACCCGTTCTAC
TATGACTATGAGACCGTTCGCAATGGGGGCCTGATCTTCGCTGGACTGGCCTTCATCGTG
GGGCTCCTCATCCTCCTCAGCAGAAGATTCCGCTGTGGGGGCAATAAGAAGCGCAGGCAA
ATCAATGAAGATGAGCCGTAA
Chromosome Location
11
Locus
11q23
External Identifiers
ResourceLink
UniProtKB IDP54710
UniProtKB Entry NameATNG_HUMAN
GenBank Protein ID1575004
GenBank Gene IDU50743
GenAtlas IDFXYD2
HGNC IDHGNC:4026
General References
  1. Kim JW, Lee Y, Lee IA, Kang HB, Choe YK, Choe IS: Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma-subunit. Biochim Biophys Acta. 1997 Feb 7;1350(2):133-5. [Article]
  2. Sweadner KJ, Wetzel RK, Arystarkhova E: Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase. Biochem Biophys Res Commun. 2000 Dec 9;279(1):196-201. [Article]
  3. Meij IC, Koenderink JB, van Bokhoven H, Assink KF, Groenestege WT, de Pont JJ, Bindels RJ, Monnens LA, van den Heuvel LP, Knoers NV: Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit. Nat Genet. 2000 Nov;26(3):265-6. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00606CyclothiazideapprovedyesinhibitorDetails
DB09479Rubidium Rb-82approved, investigationalyessubstrateDetails
DB11590ThimerosalapprovedunknownantagonistDetails
DB13620Potassium gluconateapprovedyessubstrateinducerDetails
DB09020BisacodylapprovedunknowninhibitorDetails
DB16690TegoprazaninvestigationalyesinhibitorDetails