Small ribosomal subunit protein uS12

BE0000279ProteinEscherichia coli (strain K12)rpsL

With S4 and S5 plays an important role in translational accuracy. It is acted on by 12 drugs in DrugBank.

Gene name
rpsL
UniProtKB entry
P0A7S3Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
124 residues · 13,737 Da
Also known as
30S ribosomal protein S12 · strA

Resolves to

Protein
UniProtP0A7S3UniProt nameRS12_ECOLI
Gene
NCBI Gene24912032GenBank43010
Pharmacology
KEGGecj:JW3304
Structure
PDB1M5GPDB1MJ1PDB1ZN1
Drugs

What you can answer from here — as of May 03, 2025

12DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Small ribosomal subunit protein uS12, how selective are they, and which programs against it are still in active trials?

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