Adenosine receptor A3

BE0000354ProteinHumansADORA3

G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection (PubMed:38627384, PubMed:40825947, PubMed:9837869). It is acted on by 21 drugs in DrugBank.

Gene name
ADORA3
UniProtKB entry
P0DMS8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
318 residues · 36,184 Da

Resolves to

Protein
UniProtP0DMS8UniProt nameAA3R_HUMAN
Gene
HGNCHGNC:268NCBI Gene140GenBank349449GeneCardsADORA3
Pharmacology
IUPHAR/GtoPdb21KEGGhsa:140
Structure
PDB8X16PDB8X17PDB9EBH
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenosine receptor A3, how selective are they, and which programs against it are still in active trials?

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