Glutathione reductase, mitochondrial

BE0000648ProteinHumansGSR

Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). It is acted on by 27 drugs in DrugBank.

Gene name
GSR
UniProtKB entry
P00390Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
522 residues · 56,257 Da
Also known as
1.8.1.7 · GLUR · GR · GRase · GRD1

Resolves to

Protein
UniProtP00390UniProt nameGSHR_HUMAN
Gene
HGNCHGNC:4623NCBI Gene2936GenBank31825GeneCardsGSR
Pharmacology
KEGGhsa:2936
Structure
PDB1ALGPDB1BWCPDB1DNC
Drugs

What you can answer from here — as of September 07, 2019

27DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione reductase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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