Cytochrome P450 11B1, mitochondrial

BE0000731ProteinHumansCYP11B1

A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids (PubMed:12530636, PubMed:1518866, PubMed:1775135, PubMed:18215163, PubMed:23322723, PubMed:23685396, PubMed:29277707). It is acted on by 26 drugs in DrugBank.

Gene name
CYP11B1
UniProtKB entry
P15538Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
503 residues · 57,572 Da
Also known as
CYP11B1 · CYPXIB1 · Cytochrome P-450c11 · Cytochrome P450C11 · S11BH

Resolves to

Protein
UniProtP15538UniProt nameC11B1_HUMAN
Gene
HGNCHGNC:2591NCBI Gene1584GenBank181333GeneCardsCYP11B1
Pharmacology
IUPHAR/GtoPdb1359KEGGhsa:1584
Structure
PDB6M7XPDB7E7F
Drugs

What you can answer from here — as of September 07, 2019

26DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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72+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 11B1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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