Dual specificity mitogen-activated protein kinase kinase 1

BE0000870ProteinHumansMAP2K1

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is acted on by 31 drugs in DrugBank.

Gene name
MAP2K1
UniProtKB entry
Q02750Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Residues / weight
393 residues · 43,439 Da
Also known as
2.7.12.2 · ERK activator kinase 1 · MAP kinase kinase 1 · MAPK/ERK kinase 1 · MAPKK 1

Resolves to

Protein
UniProtQ02750UniProt nameMP2K1_HUMAN
Gene
HGNCHGNC:6840NCBI Gene5604GenBank188569GeneCardsMAP2K1
Pharmacology
IUPHAR/GtoPdb2062KEGGhsa:5604
Structure
PDB1S9JPDB2P55PDB3DV3
Drugs

What you can answer from here — as of September 07, 2019

31DrugsApproved to experimental, with action, bond type and pharmacological action
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14Clinical trialsTrials of drugs acting on it, by phase and status
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56GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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126+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity mitogen-activated protein kinase kinase 1, how selective are they, and which programs against it are still in active trials?

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