Zinc sulfate

Identification

Summary

Zinc sulfate is a drug used to replenish low levels of zinc or prevent zinc deficiency, or to test for zinc deficiency.

Brand Names
Anodan-HC, Anusol, Egozinc, Multitrace-4, Multitrace-5, Proctodan-HC, Rectogel, Riva-sol HC
Generic Name
Zinc sulfate
DrugBank Accession Number
DB09322
Background

Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 161.472
Monoisotopic: 159.880875756
Chemical Formula
O4SZn
Synonyms
  • Zinc sulfate (anhydrous)
  • Zinc sulfate anhydrous
  • Zinc sulfate, anhydrous
  • Zinc sulphate
  • Zinc sulphate anhydrous
  • Zinc sulphate, anhydrous

Pharmacology

Indication

This medication is a mineral used to treat or prevent low levels of zinc alone and together with oral rehydration therapy (ORT). It is also used as a topical astringent. Zinc Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for TPN.

Pharmacology
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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Zinc has been identified as a cofactor for over 70 different enzymes, including alkaline phosphatase, lactic dehydrogenase and both RNA and DNA polymerase. Zinc facilitates wound healing, helps maintain normal growth rates, normal skin hydration and the senses of taste and smell.

Mechanism of action

Zinc inhibits cAMP-induced, chloride-dependent fluid secretion by inhibiting basolateral potassium (K) channels, in in-vitro studies with rat ileum. This study has also shown the specificity of Zn to cAMP-activated K channels, because zinc did not block the calcium (Ca)-mediated K channels. As this study was not performed in Zn-deficient animals, it provides evidence that Zn is probably effective in the absence of Zn deficiency. Zinc also improves the absorption of water and electrolytes, improves regeneration of the intestinal epithelium, increases the levels of brush border enzymes, and enhances the immune response, allowing for a better clearance of the pathogens.

Absorption

Approximately 20 to 30% of dietary zinc is absorbed, primarily from the duodenum and ileum. The amount absorbed is dependent on the bioavailability from food. Zinc is the most bioavailable from red meat and oysters. Phytates may impair absorption by chelation and formation of insoluble complexes at an alkaline pH. After absorption, zinc is bound in the intestine to the protein metallothionein. Endogenous zinc can be reabsorbed in the ileum and colon, creating an enteropancreatic circulation of zinc.

Volume of distribution

After absorption zinc is bound to protein metallothionein in the intestines. Zinc is widely distributed throughout the body. It is primarily stored in RBCs, WBCs, muscles, bones, Skin, Kidneys, Liver, Pancreas, retina, and prostate.

Protein binding

Zinc is 60% bound to albumin; 30 to 40% bound to alpha-2 macroglobulin or transferrin; and 1% bound to amino acids, primarily histidine and cysteine.

Metabolism
Not Available
Route of elimination

Primarily fecal (approximately 90%); to a lesser extent in the urine and in perspiration.

Half-life

3 hours

Clearance

Not Available

Adverse Effects
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Toxicity

Human : TDLo ( Oral) 45mg/kg/7D-C : Normocytic anemia, pulse rate increase without fall inBP Human: TDLo (oral) 106mg/kg : Hypermotylity, diarrhea Mouse ; LD50 Oral : 245mg/kg Mouse : LD50 : subcutaneous : 781mg/kg

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
CarbamazepineZinc sulfate can cause a decrease in the absorption of Carbamazepine resulting in a reduced serum concentration and potentially a decrease in efficacy.
CeftibutenZinc sulfate can cause a decrease in the absorption of Ceftibuten resulting in a reduced serum concentration and potentially a decrease in efficacy.
CephalexinZinc sulfate can cause a decrease in the absorption of Cephalexin resulting in a reduced serum concentration and potentially a decrease in efficacy.
CinoxacinZinc sulfate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
CiprofloxacinZinc sulfate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
DeferasiroxZinc sulfate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
DeferiproneZinc sulfate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
DelafloxacinZinc sulfate can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
DemeclocyclineZinc sulfate can cause a decrease in the absorption of Demeclocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
DolutegravirZinc sulfate can cause a decrease in the absorption of Dolutegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Interactions
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Food Interactions
  • Avoid milk and dairy products. Separate the use of zinc from these products by at least 2 hours before administration. Separate for 2 hours after administration if these products also contain phosphorus.
  • Do not take with bran and high fiber foods. For optimal absorption, take zinc at least 2 hours before or after eating high-fiber foods.
  • Take on an empty stomach. Take at least 1 hour before and 2 hours after eating for optimal absorption. Zinc can be taken with food to reduce gastrointestinal upset.

Products

Products
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Product Ingredients
IngredientUNIICASInChI Key
Zinc sulfate heptahydrateN57JI2K7WP7446-20-0RZLVQBNCHSJZPX-UHFFFAOYSA-L
Zinc sulfate hexahydrateNot Available13986-24-8QWCKCWSBAUZZLF-UHFFFAOYSA-L
Zinc sulfate monohydratePTX099XSF17446-19-7RNZCSKGULNFAMC-UHFFFAOYSA-L
Active Moieties
NameKindUNIICASInChI Key
Zinc cationionic13S1S8SF3723713-49-7PTFCDOFLOPIGGS-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Zinc SulfateInjection, solution5 mg/1mLIntravenousAMERICAN REGENT, INC.1990-09-302021-02-28US flag
Zinc SulfateInjection, solution1 mg/1mLIntravenousAMERICAN REGENT, INC.1990-09-302021-05-31US flag
Zinc Tally Liq 13.5mg/10mlLiquid13.5 mg / 10 mLOralMetagenics, Inc.1989-12-311996-10-02Canada flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Anu-aide - Ont Top 0.5%Ointment.5 %TopicalTechnilab Pharma Inc.1997-07-302005-08-05Canada flag
Ascazin Capsules (Zinc 50.96mg)CapsuleOralUNIMED SDN BHD2020-09-08Not applicableMalaysia flag
EYE GLO RELIEF EYE DROPS 0.25%w/vSolution / dropsOphthalmicDuopharma Marketing Sdn. Bhd.2020-09-08Not applicableMalaysia flag
ซิงค์ สตาร์Tablet, film coated25 mgบริษัท ห้างขายยาตราเจ็ดดาว จำกัด2018-03-19Not applicableThailand flag
ซิงค์แคปส์Capsule25 mgOralบริษัท ฟาร์สเป็ค จำกัด จำกัด1989-10-10Not applicableThailand flag
ซิงค์โพสTablet, coated25 mgOralบริษัท ยูโทเปี้ยน จำกัด1996-12-16Not applicableThailand flag
สังกะสีTablet25 mgOralบริษัท ฟาร์มา ซัพพลาย จำกัด จำกัด1990-08-31Not applicableThailand flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
8-symptom ReliefZinc sulfate (0.25 % w/v) + Tetrahydrozoline hydrochloride (0.05 % w/v)SolutionOphthalmicTEVA Canada Limited2016-07-22Not applicableCanada flag
Allergy Eye DropsZinc sulfate (0.25 % w/v) + Tetrahydrozoline hydrochloride (0.05 % w/v)SolutionOphthalmicTEVA Canada Limited2007-05-23Not applicableCanada flag
Allergy Eye DropsZinc sulfate (0.25 %) + Tetrahydrozoline hydrochloride (0.05 %)Solution / dropsOphthalmicAlcon, Inc.2005-06-242009-04-24Canada flag
Allergy Eye DropsZinc sulfate (0.25 % w/v) + Tetrahydrozoline hydrochloride (0.05 % w/v)SolutionOphthalmicKc Pharmaceuticals, Inc.Not applicableNot applicableCanada flag
Anodan-HC 10mg SuppositoriesZinc sulfate (10 mg) + Hydrocortisone acetate (10 mg)SuppositoryRectalOdan Laboratories Ltd1998-08-13Not applicableCanada flag
Anodan-HC OintmentZinc sulfate (0.5 %) + Hydrocortisone acetate (0.5 %)OintmentRectal; TopicalOdan Laboratories Ltd1995-12-31Not applicableCanada flag
Anodan-plusZinc sulfate (10 mg) + Pramoxine hydrochloride (20 mg)SuppositoryRectalOdan Laboratories LtdNot applicableNot applicableCanada flag
Anodan-plus OintmentZinc sulfate (0.5 %) + Pramoxine hydrochloride (1 %)OintmentRectalOdan Laboratories LtdNot applicableNot applicableCanada flag
Anugesic-HC OintmentZinc sulfate (0.5 %) + Hydrocortisone acetate (0.5 %) + Pramoxine hydrochloride (1 %)OintmentRectalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1981-12-312021-02-11Canada flag
Anugesic-HC SuppositoriesZinc sulfate (10 mg) + Hydrocortisone acetate (10 mg) + Pramoxine hydrochloride (20 mg)SuppositoryRectalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1978-12-312020-08-31Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
MEDIZINC SURUP 100 MLZinc sulfate (100 ml)SyrupOralCASEL ECZACI CAHİT SELİMOĞLU İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-14Not applicableTurkey flag
Multitrace -4Zinc sulfate heptahydrate (22 mg/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-11-29Not applicableUS flag
Multitrace -4Zinc sulfate heptahydrate (22 mg/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-12-07Not applicableUS flag
Multitrace -4 PediatricZinc sulfate heptahydrate (4.39 mg/1mL) + Chromic chloride hexahydrate (5.12 ug/1mL) + Cupric sulfate pentahydrate (0.4 mg/1mL) + Manganese sulfate (77 ug/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-12-09Not applicableUS flag
Multitrace-4Zinc sulfate heptahydrate (4.39 mg/1mL) + Chromic chloride hexahydrate (20.5 ug/1mL) + Cupric sulfate pentahydrate (1.57 mg/1mL) + Manganese sulfate (0.308 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1994-02-17Not applicableUS flag
Multitrace-4 NeonatalZinc sulfate heptahydrate (6.6 mg/1mL) + Chromic chloride hexahydrate (4.36 ug/1mL) + Cupric sulfate pentahydrate (0.39 mg/1mL) + Manganese sulfate (77 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1990-09-30Not applicableUS flag
Multitrace-5Zinc sulfate heptahydrate (4.39 mg/1mL) + Chromic chloride hexahydrate (20.5 ug/1mL) + Cupric sulfate pentahydrate (1.57 mg/1mL) + Manganese sulfate (0.308 mg/1mL) + Selenious acid (32.7 ug/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1994-02-17Not applicableUS flag
Multitrace-5Zinc sulfate heptahydrate (22 mg/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Selenious acid (98 ug/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-09-14Not applicableUS flag
Multitrace-5Zinc sulfate heptahydrate (22 mg/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Cupric sulfate pentahydrate (3.93 mg/1mL) + Manganese sulfate (1.54 mg/1mL) + Selenious acid (98 ug/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-12-17Not applicableUS flag
Trace Elements 4Zinc sulfate heptahydrate (2.2 mg/1mL) + Chromic chloride hexahydrate (5.12 ug/1mL) + Cupric sulfate pentahydrate (0.4 mg/1mL) + Manganese sulfate (92.3 ug/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1994-02-24Not applicableUS flag

Categories

ATC Codes
C05AX04 — Zinc preparationsA12CB01 — Zinc sulfate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as transition metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is a transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Transition metal oxoanionic compounds
Sub Class
Transition metal sulfates
Direct Parent
Transition metal sulfates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Inorganic oxide / Inorganic salt / Transition metal sulfate
Molecular Framework
Not Available
External Descriptors
zinc molecular entity, metal sulfate (CHEBI:35176)
Affected organisms
Not Available

Chemical Identifiers

UNII
0J6Z13X3WO
CAS number
7733-02-0
InChI Key
NWONKYPBYAMBJT-UHFFFAOYSA-L
InChI
InChI=1S/H2O4S.Zn/c1-5(2,3)4;/h(H2,1,2,3,4);/q;+2/p-2
IUPAC Name
zinc(2+) ion sulfate
SMILES
[Zn++].[O-]S([O-])(=O)=O

References

General References
  1. DRUGS.COM [Link]
  2. NCBI [Link]
  3. ChemIDplus [Link]
  4. WebMD [Link]
  5. Pubchem [Link]
  6. DAILYMED [Link]
PubChem Compound
24424
PubChem Substance
310265204
ChemSpider
22833
RxNav
39954
ChEBI
35176
ChEMBL
CHEMBL1200929
PharmGKB
PA451971
Wikipedia
Zinc_sulfate
AHFS Codes
  • 88:29.00* — Minerals
  • 84:92.00 — Misc. Skin and Mucous Membrane Agents

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionImmunosuppression / Splenectomy; Status / Thalassaemic disorders1
4CompletedTreatmentAcute Diarrhoea / Acute Gastroenteritis1
4CompletedTreatmentCoronavirus Disease 2019 (COVID‑19)1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4CompletedTreatmentOsteoarthritis of the Knee1
4Not Yet RecruitingTreatmentChronic Lung Disease of Prematurity / Early-Onset Sepses, Neonatal / Infant, Small for Gestational Age / Necrotizing Enterocolitis / Periventricular haemorrhage neonatal / Retinopathy of Prematurity1
4TerminatedSupportive CareCancer-related Malnutrition1
4TerminatedSupportive CareIllness, Critical1
4Unknown StatusTreatmentAppetite Disorders1
3CompletedPreventionNutrition1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionOphthalmic
OintmentRectal; Topical
OintmentTopical.5 %
SuppositoryRectal
CapsuleOral
SuspensionOral
SprayTopical
LiquidTopical
Solution / dropsOphthalmic
SyrupOral
EmulsionParenteral
SyrupOral
SolutionOral
OintmentRectal
Tablet, coatedOral150 mcg
Injection, emulsionIntravenous
GelTopical
Injection, solution, concentrateIntravenous
Injection, solutionIntravenous
SolutionOral
Solution / dropsOphthalmic
TabletOral
OintmentTopical
EmulsionIntravenous
Capsule, liquid filledOral
CapsuleOral
Capsule, gelatin coatedOral
Tablet, film coatedOral
GranuleOral
Injection, solutionIntravenous1 mg/1mL
Injection, solutionIntravenous5 mg/1mL
Solution / drops; suspension / drops
LiquidOral13.5 mg / 10 mL
Tablet, effervescentOral
TabletOral
Tablet, sugar coatedOral
Capsule, liquid filledOral
Tablet, film coated
Tablet, solubleOral
Tablet, film coated25 mg
CapsuleOral25 mg
Tablet, coatedOral25 mg
TabletOral25 mg
LiquidOphthalmic
Tablet, film coated
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area80.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.53 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Cofactor
General Function
Metal ion binding
Specific Function
Not Available
Gene Name
ALPPL2
Uniprot ID
P10696
Uniprot Name
Alkaline phosphatase, placental-like
Molecular Weight
57376.515 Da
References
  1. DAILYMED [Link]

Drug created on November 17, 2015 17:46 / Updated on May 15, 2021 12:14