Alpha-1-antitrypsin

BE0000952ProteinHumansSERPINA1

Inhibitor of serine proteases. It is acted on by 16 drugs in DrugBank.

Gene name
SERPINA1
UniProtKB entry
P01009Swiss-Prot
Cellular location
Secreted
Residues / weight
418 residues · 46,736 Da
Also known as
AAT · Alpha-1 protease inhibitor · Alpha-1-antiproteinase · PI · Serpin A1

Resolves to

Protein
UniProtP01009UniProt nameA1AT_HUMAN
Gene
HGNCHGNC:8941NCBI Gene5265GenBank177829GeneCardsSERPINA1
Pharmacology
KEGGhsa:5265
Structure
PDB1ATUPDB1D5SPDB1EZX
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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15Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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85+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-1-antitrypsin, how selective are they, and which programs against it are still in active trials?

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