Cyclic AMP-responsive element-binding protein 1

BE0000958ProteinHumansCREB1

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
CREB1
UniProtKB entry
P16220Swiss-Prot
Cellular location
Nucleus
Residues / weight
327 residues · 35,136 Da
Also known as
cAMP-responsive element-binding protein 1 · CREB-1

Resolves to

Protein
UniProtP16220UniProt nameCREB1_HUMAN
Gene
HGNCHGNC:2345NCBI Gene1385GenBank240429GeneCardsCREB1
Pharmacology
KEGGhsa:1385
Structure
PDB2LXTPDB5ZK1PDB5ZKO
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
24GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
35+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Cyclic AMP-responsive element-binding protein 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In