Mitogen-activated protein kinase 14

BE0001019ProteinHumansMAPK14

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. It is acted on by 77 drugs in DrugBank.

Gene name
MAPK14
UniProtKB entry
Q16539Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
360 residues · 41,293 Da
Also known as
2.7.11.24 · CSAID-binding protein · CSBP · CSBP1 · CSBP2

Resolves to

Protein
UniProtQ16539UniProt nameMK14_HUMAN
Gene
HGNCHGNC:6876NCBI Gene1432GenBank603917GeneCardsMAPK14
Pharmacology
IUPHAR/GtoPdb1499KEGGhsa:1432
Structure
PDB11OYPDB1A9UPDB1BL6
Drugs

What you can answer from here — as of September 07, 2019

77DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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287+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase 14, how selective are they, and which programs against it are still in active trials?

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