Hexokinase-4

BE0001056ProteinHumansGCK

Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively) (PubMed:11916951, PubMed:15277402, PubMed:17082186, PubMed:18322640, PubMed:19146401, PubMed:25015100, PubMed:7742312, PubMed:8325892). It is acted on by 16 drugs in DrugBank.

Gene name
GCK
UniProtKB entry
P35557Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
465 residues · 52,191 Da
Also known as
2.7.1.1 · Glucokinase · Hexokinase type IV · Hexokinase-D · HK IV

Resolves to

Protein
UniProtP35557UniProt nameHXK4_HUMAN
Gene
HGNCHGNC:4195NCBI Gene2645GenBank179427GeneCardsGCK
Pharmacology
IUPHAR/GtoPdb2798KEGGhsa:2645
Structure
PDB1V4SPDB1V4TPDB3A0I
Drugs

What you can answer from here — as of September 03, 2024

16DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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75+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hexokinase-4, how selective are they, and which programs against it are still in active trials?

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