Protein kinase C alpha type

BE0001132ProteinHumansPRKCA

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets... It is acted on by 20 drugs in DrugBank.

Gene name
PRKCA
UniProtKB entry
P17252Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
672 residues · 76,749 Da
Also known as
2.7.11.13 · PKC-A · PKC-alpha · PKCA · PRKACA

Resolves to

Protein
UniProtP17252UniProt nameKPCA_HUMAN
Gene
HGNCHGNC:9393NCBI Gene5578GenBank35483GeneCardsPRKCA
Pharmacology
IUPHAR/GtoPdb1482KEGGhsa:5578
Structure
PDB2ELIPDB3IW4PDB4DNL
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
18GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
76+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Protein kinase C alpha type, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In