Integrin beta-3

BE0001155ProteinHumansITGB3

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor (VWF). It is acted on by 36 drugs in DrugBank.

Gene name
ITGB3
UniProtKB entry
P05106Swiss-Prot
Cellular location
Cell membrane
Residues / weight
788 residues · 87,057 Da
Also known as
GP3A · GPIIIa · Platelet membrane glycoprotein IIIa

Resolves to

Protein
UniProtP05106UniProt nameITB3_HUMAN
Gene
HGNCHGNC:6156NCBI Gene3690GenBank306786GeneCardsITGB3
Pharmacology
IUPHAR/GtoPdb2457KEGGhsa:3690
Structure
PDB1JV2PDB1KUPPDB1KUZ
Drugs

What you can answer from here — as of September 07, 2019

36DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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49GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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143+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Integrin beta-3, how selective are they, and which programs against it are still in active trials?

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