3-phosphoinositide-dependent protein kinase 1

BE0001193ProteinHumansPDPK1

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:16207722, PubMed:16251192, PubMed:17327236, PubMed:17371830, PubMed:18835241, PubMed:9094314, PubMed:9368760, PubMed:9445476, PubMed:9445477,... It is acted on by 17 drugs in DrugBank.

Gene name
PDPK1
UniProtKB entry
O15530Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
556 residues · 63,151 Da
Also known as
2.7.11.1 · hPDK1 · PDK1

Resolves to

Protein
UniProtO15530UniProt namePDPK1_HUMAN
Gene
HGNCHGNC:8816NCBI Gene5170GenBank2407613GeneCardsPDPK1
Pharmacology
IUPHAR/GtoPdb1519KEGGhsa:5170
Structure
PDB1H1WPDB1OKYPDB1OKZ
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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82+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3-phosphoinositide-dependent protein kinase 1, how selective are they, and which programs against it are still in active trials?

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