Tyrosine-protein kinase SYK

BE0001316ProteinHumansSYK

Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). It is acted on by 21 drugs in DrugBank.

Gene name
SYK
UniProtKB entry
P43405Swiss-Prot
Cellular location
Cell membrane
Residues / weight
635 residues · 72,066 Da
Also known as
2.7.10.2 · p72-Syk · Spleen tyrosine kinase

Resolves to

Protein
UniProtP43405UniProt nameKSYK_HUMAN
Gene
HGNCHGNC:11491NCBI Gene6850GenBank496900GeneCardsSYK
Pharmacology
IUPHAR/GtoPdb2230KEGGhsa:6850
Structure
PDB1A81PDB1CSYPDB1CSZ
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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46GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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98+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase SYK, how selective are they, and which programs against it are still in active trials?

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