Tubulin alpha-1A chain

BE0001340ProteinHumansTUBA1A

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. It is acted on by 10 drugs in DrugBank.

Gene name
TUBA1A
UniProtKB entry
Q71U36Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
451 residues · 50,135 Da
Also known as
3.6.5.- · Alpha-tubulin 3 · TUBA3 · Tubulin alpha-3 chain · Tubulin B-alpha-1

Resolves to

Protein
UniProtQ71U36UniProt nameTBA1A_HUMAN
Gene
HGNCHGNC:20766NCBI Gene7846GenBank37492GeneCardsTUBA1A
Pharmacology
KEGGhsa:7846
Structure
PDB22AJPDB22AKPDB5JCO
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tubulin alpha-1A chain, how selective are they, and which programs against it are still in active trials?

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