Beta-lactamase

BE0001358ProteinEscherichia coli (strain K12)ampC

Class C beta-lactamase which confers resistance to penicillins and cephalosporins (PubMed:12323371, PubMed:17956081, PubMed:33199391, PubMed:6998377). It is acted on by 42 drugs in DrugBank.

Gene name
ampC
UniProtKB entry
P00811Swiss-Prot
Cellular location
Periplasm
Residues / weight
377 residues · 41,555 Da
Also known as
3.5.2.6 · ampA · Cephalosporinase · CSase

Resolves to

Protein
UniProtP00811UniProt nameAMPC_ECOLI
Gene
NCBI Gene948669GenBank145267
Pharmacology
KEGGecj:JW4111
Structure
PDB1C3BPDB1FCMPDB1FCN
Drugs

What you can answer from here — as of September 07, 2019

42DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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67+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-lactamase, how selective are they, and which programs against it are still in active trials?

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