Calreticulin

BE0002109ProteinHumansCALR

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. It is acted on by 11 drugs in DrugBank.

Gene name
CALR
UniProtKB entry
P27797Swiss-Prot
Cellular location
Endoplasmic reticulum lumen
Residues / weight
417 residues · 48,141 Da
Also known as
Calregulin · CRP55 · CRTC · Endoplasmic reticulum resident protein 60 · ERp60

Resolves to

Protein
UniProtP27797UniProt nameCALR_HUMAN
Gene
HGNCHGNC:1455NCBI Gene811GenBank337487GeneCardsCALR
Pharmacology
KEGGhsa:811
Structure
PDB2CLRPDB3DOWPDB3POS
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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51GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calreticulin, how selective are they, and which programs against it are still in active trials?

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