Cyclin-dependent kinase 6

BE0002212ProteinHumansCDK6

Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. It is acted on by 20 drugs in DrugBank.

Gene name
CDK6
UniProtKB entry
Q00534Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
326 residues · 36,938 Da
Also known as
2.7.11.22 · CDKN6 · Cell division protein kinase 6 · Serine/threonine-protein kinase PLSTIRE

Resolves to

Protein
UniProtQ00534UniProt nameCDK6_HUMAN
Gene
HGNCHGNC:1777NCBI Gene1021GenBank36623GeneCardsCDK6
Pharmacology
IUPHAR/GtoPdb1978KEGGhsa:1021
Structure
PDB1BI7PDB1BI8PDB1BLX
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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23Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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94+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclin-dependent kinase 6, how selective are they, and which programs against it are still in active trials?

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