Adenosine deaminase

BE0002214ProteinHumansADA

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:16670267, PubMed:23193172, PubMed:26166670, PubMed:8452534, PubMed:9361033). It is acted on by 34 drugs in DrugBank.

Gene name
ADA
UniProtKB entry
P00813Swiss-Prot
Cellular location
Cell membrane
Residues / weight
363 residues · 40,764 Da
Also known as
3.5.4.4 · ADA1 · Adenosine aminohydrolase

Resolves to

Protein
UniProtP00813UniProt nameADA_HUMAN
Gene
HGNCHGNC:186NCBI Gene100GenBank28380GeneCardsADA
Pharmacology
IUPHAR/GtoPdb1230KEGGhsa:100
Structure
PDB3IARPDB7RTG
Drugs

What you can answer from here — as of September 07, 2019

34DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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113+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenosine deaminase, how selective are they, and which programs against it are still in active trials?

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