8-Chloroadenosine

DB16075InvestigationalSmall molecule

8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia).

Mechanism: Pharmacologically active on Mitochondrial ATP synthase F1 domain
Curator reviewed
Formula / weight: C₁₀H₁₂ClN₅O₄ · 301.69 g/mol (avg)
Also known as: 8-Chloro-adenosine · Adenosine, 8-chloro-

Resolves to

Compound

UNIIPA05MFH3I7CAS34408-14-5

Structure

InChIKeyMHDPPLULTMGBSI-UUOKFMHZSA-NSMILESNC1=NC=NC2=C1N=C(Cl)N2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

What you can answer from here — as of August 08, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which companies are running trials of 8-Chloroadenosine, in which indications and phases, and which of those programs are still active?

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