Voltage-dependent L-type calcium channel subunit alpha-1D

BE0002359ProteinHumansCACNA1D

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell... It is acted on by 17 drugs in DrugBank.

Gene name
CACNA1D
UniProtKB entry
Q01668Swiss-Prot
Cellular location
Membrane
Residues / weight
2,161 residues · 245,139 Da
Also known as
CACH3 · CACN4 · CACNL1A2 · Calcium channel, L type, alpha-1 polypeptide, isoform 2 · CCHL1A2

Resolves to

Protein
UniProtQ01668UniProt nameCAC1D_HUMAN
Gene
HGNCHGNC:1391NCBI Gene776GenBank179764GeneCardsCACNA1D
Pharmacology
IUPHAR/GtoPdb530KEGGhsa:776
Structure
PDB3LV3PDB7UHFPDB7UHG
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent L-type calcium channel subunit alpha-1D, how selective are they, and which programs against it are still in active trials?

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