Histone deacetylase 2

BE0002366ProteinHumansHDAC2

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). It is acted on by 17 drugs in DrugBank.

Gene name
HDAC2
UniProtKB entry
Q92769Swiss-Prot
Cellular location
Nucleus
Residues / weight
488 residues · 55,364 Da
Also known as
3.5.1.98 · HD2 · Protein deacylase HDAC2

Resolves to

Protein
UniProtQ92769UniProt nameHDAC2_HUMAN
Gene
HGNCHGNC:4853NCBI Gene3066GenBank1667394GeneCardsHDAC2
Pharmacology
IUPHAR/GtoPdb2616KEGGhsa:3066
Structure
PDB3MAXPDB4LXZPDB4LY1
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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85+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone deacetylase 2, how selective are they, and which programs against it are still in active trials?

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