Peptidoglycan D,D-transpeptidase MrdA

BE0003579ProteinEscherichia coli (strain K12)mrdA

Catalyzes cross-linking of the peptidoglycan cell wall (PubMed:3009484). It is acted on by 16 drugs in DrugBank.

Gene name
mrdA
UniProtKB entry
P0AD65Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
633 residues · 70,856 Da
Also known as
3.4.16.4 · Class B penicillin-binding protein 2 · PBP-2 · PBP2 · pbpA

Resolves to

Protein
UniProtP0AD65UniProt nameMRDA_ECOLI
Gene
NCBI Gene945240GenBank42314
Pharmacology
KEGGecj:JW0630
Drugs

What you can answer from here — as of May 03, 2025

16DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidoglycan D,D-transpeptidase MrdA, how selective are they, and which programs against it are still in active trials?

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