Arylamine N-acetyltransferase 2

BE0003607ProteinHumansNAT2

Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates (PubMed:12222688, PubMed:7915226). It is acted on by 13 drugs in DrugBank.

Gene name
NAT2
UniProtKB entry
P11245Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
290 residues · 33,570 Da
Also known as
2.3.1.5 · AAC2 · Arylamide acetylase 2 · N-acetyltransferase type 2 · N-hydroxyarylamine O-acetyltransferase

Resolves to

Protein
UniProtP11245UniProt nameARY2_HUMAN
Gene
HGNCHGNC:7646NCBI Gene10GenBank219412GeneCardsNAT2
Pharmacology
KEGGhsa:10
Structure
PDB2PFR
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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8Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Arylamine N-acetyltransferase 2, how selective are they, and which programs against it are still in active trials?

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