NAD-dependent protein deacetylase sirtuin-3, mitochondrial

BE0004547ProteinHumansSIRT3

NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:19535340, PubMed:23283301, PubMed:24121500, PubMed:24252090). It is acted on by 1 drug in DrugBank.

Gene name
SIRT3
UniProtKB entry
Q9NTG7Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
399 residues · 43,573 Da
Also known as
2.3.1.286 · hSIRT3 · NAD-dependent protein delactylase sirtuin-3 · Regulatory protein SIR2 homolog 3 · SIR2-like protein 3

Resolves to

Protein
UniProtQ9NTG7UniProt nameSIR3_HUMAN
Gene
HGNCHGNC:14931NCBI Gene23410GeneCardsSIRT3
Pharmacology
IUPHAR/GtoPdb2709KEGGhsa:23410
Structure
PDB3GLRPDB3GLSPDB3GLT
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on NAD-dependent protein deacetylase sirtuin-3, mitochondrial, and which indications are they being tested in?

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