Anoctamin-1

BE0004746ProteinHumansANO1

Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). It is acted on by 9 drugs in DrugBank.

Gene name
ANO1
UniProtKB entry
Q5XXA6Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
986 residues · 114,077 Da
Also known as
Discovered on gastrointestinal stromal tumors protein 1 · DOG1 · Oral cancer overexpressed protein 2 · ORAOV2 · TAOS2

Resolves to

Protein
UniProtQ5XXA6UniProt nameANO1_HUMAN
Gene
HGNCHGNC:21625NCBI Gene55107GeneCardsANO1
Pharmacology
IUPHAR/GtoPdb708KEGGhsa:55107
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Anoctamin-1, how selective are they, and which programs against it are still in active trials?

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