Sulfotransferase 1A3

BE0004767ProteinHumansSULT1A3

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine, (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs (PubMed:8093002, PubMed:29524394, PubMed:14622112, PubMed:15358107). It is acted on by 9 drugs in DrugBank.

Gene name
SULT1A3
UniProtKB entry
P0DMM9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
295 residues · 34,196 Da
Also known as
2.8.2.1 · Aryl sulfotransferase 1A3/1A4 · Catecholamine-sulfating phenol sulfotransferase · HAST3 · M-PST

Resolves to

Protein
UniProtP0DMM9UniProt nameST1A3_HUMAN
Gene
HGNCHGNC:11455NCBI Gene6818GeneCardsSULT1A3
Pharmacology
KEGGhsa:6818
Structure
PDB1CJMPDB2A3R
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sulfotransferase 1A3, how selective are they, and which programs against it are still in active trials?

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