Ras-related C3 botulinum toxin substrate 2
Details
- Name
- Ras-related C3 botulinum toxin substrate 2
- Kind
- protein
- Synonyms
- GX
- p21-Rac2
- Small G protein
- Gene Name
- RAC2
- UniProtKB Entry
- P15153Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0013347|Ras-related C3 botulinum toxin substrate 2 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ PTRQQKRACSLL
- Number of residues
- 192
- Molecular Weight
- 21428.575
- Theoretical pI
- Not Available
- GO Classification
- Processeschemotaxis / erythrocyte enucleation / G protein-coupled receptor signaling pathway / mast cell proliferation / positive regulation of mast cell proliferation / respiratory burst / small GTPase-mediated signal transductionComponentsendoplasmic reticulum membrane / mitochondrial outer membrane / NADPH oxidase complex
- General Function
- Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase
- Specific Function
- GTP binding
- Pfam Domain Function
- Ras (PF00071)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0013348|Ras-related C3 botulinum toxin substrate 2 (RAC2) ATGCAGGCCATCAAGTGTGTGGTGGTGGGAGATGGGGCCGTGGGCAAGACCTGCCTTCTC ATCAGCTACACCACCAACGCCTTTCCCGGAGAGTACATCCCCACCGTGTTTGACAACTAT TCAGCCAATGTGATGGTGGACAGCAAGCCAGTGAACCTGGGGCTGTGGGACACTGCTGGG CAGGAGGACTACGACCGTCTCCGGCCGCTCTCCTATCCACAGACGGACGTCTTCCTCATC TGCTTCTCCCTCGTCAGCCCAGCCTCTTATGAGAACGTCCGCGCCAAGTGGTTCCCAGAA GTGCGGCACCACTGCCCCAGCACACCCATCATCCTGGTGGGCACCAAGCTGGACCTGCGG GACGACAAGGACACCATCGAGAAACTGAAGGAGAAGAAGCTGGCTCCCATCACCTACCCG CAGGGCCTGGCACTGGCCAAGGAGATTGACTCGGTGAAATACCTGGAGTGCTCAGCTCTC ACCCAGAGAGGCCTGAAAACCGTGTTCGACGAGGCCATCCGGGCCGTGCTGTGCCCTCAG CCCACGCGGCAGCAGAAGCGCGCCTGCAGCCTCCTCTAG
- Chromosome Location
- 22
- Locus
- 22q13.1
- External Identifiers
Resource Link UniProtKB ID P15153 UniProtKB Entry Name RAC2_HUMAN GeneCard ID RAC2 HGNC ID HGNC:9802 PDB ID(s) 1DS6, 2W2T, 2W2V, 2W2X KEGG ID hsa:5880 NCBI Gene ID 5880 - General References
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Associated Data
- Drug Relations
- Not Available