The DNA sequence of human chromosome 22.

Article Details


Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.

The DNA sequence of human chromosome 22.

Nature. 1999 Dec 2;402(6761):489-95.

PubMed ID
10591208 [ View in PubMed

Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.

DrugBank Data that Cites this Article

NameUniProt ID
Voltage-dependent T-type calcium channel subunit alpha-1IQ9P0X4Details
Beta-adrenergic receptor kinase 2P35626Details
Peroxisome proliferator-activated receptor alphaQ07869Details
SEC14-like protein 4Q9UDX3Details
NADH-cytochrome b5 reductase 3P00387Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6P56556Details
Choline/ethanolamine kinaseQ9Y259Details
SEC14-like protein 2O76054Details
Pyridoxal phosphate phosphataseQ96GD0Details
SEC14-like protein 3Q9UDX4Details
Monocarboxylate transporter 3O95907Details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialO75600Details
Interleukin-2 receptor subunit betaP14784Details
Phosphatidylserine decarboxylase proenzymeQ9UG56Details
Heme oxygenase 1P09601Details
Translocator proteinP30536Details
Glutathione S-transferase theta-1P30711Details
Gamma-glutamyltranspeptidase 1P19440Details
Mitogen-activated protein kinase 1P28482Details
85/88 kDa calcium-independent phospholipase A2O60733Details
Tubulin alpha-8 chainQ9NY65Details
Catechol O-methyltransferaseP21964Details
Cytokine receptor common subunit betaP32927Details
Thymidine phosphorylaseP19971Details
Proline dehydrogenase 1, mitochondrialO43272Details
Cytochrome P450 2D6P10635Details
Mitogen-activated protein kinase 12P53778Details
Arylsulfatase AP15289Details
Metalloproteinase inhibitor 3P35625Details
Serine/threonine-protein kinase Chk2O96017Details
Thioredoxin reductase 2, mitochondrialQ9NNW7Details
Mitogen-activated protein kinase 11Q15759Details
Melanin-concentrating hormone receptor 1Q99705Details
Platelet-derived growth factor subunit BP01127Details
Casein kinase I isoform epsilonP49674Details
Histone deacetylase 10Q969S8Details
Somatostatin receptor type 3P32745Details
Malonyl-CoA-acyl carrier protein transacylase, mitochondrialQ8IVS2Details
60S ribosomal protein L3P39023Details
NHP2-like protein 1P55769Details
Cytochrome b-c1 complex subunit 9Q9UDW1Details
MKL/myocardin-like protein 1Q969V6Details
tRNA-splicing ligase RtcB homologQ9Y3I0Details
Meiotic recombination protein DMC1/LIM15 homologQ14565Details
Thiosulfate sulfurtransferaseQ16762Details
Parvalbumin alphaP20472Details
Aconitate hydratase, mitochondrialQ99798Details
Glutathione S-transferase theta-2P0CG29Details
Sodium/glucose cotransporter 1P13866Details
Ras-related C3 botulinum toxin substrate 2P15153Details
Neutrophil cytosol factor 4Q15080Details
Cyclic AMP-dependent transcription factor ATF-4P18848Details
Voltage-dependent calcium channel gamma-2 subunitQ9Y698Details
Inward rectifier potassium channel 4P48050Details
Solute carrier family 2, facilitated glucose transporter member 11Q9BYW1Details
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Q15750Details
Ran-specific GTPase-activating proteinP43487Details
14-3-3 protein etaQ04917Details
Immunoglobulin lambda-like polypeptide 1P15814Details
Apolipoprotein L1O14791Details
Immunoglobulin lambda variable 3-21P80748Details
LIM domain kinase 2P53671Details
Serine/threonine-protein kinase pim-3Q86V86Details
Sulfotransferase 4A1Q9BR01Details
P2X purinoceptor 6O15547Details
V-type proton ATPase subunit E 1P36543Details
Glutathione S-transferase theta-2BP0CG30Details
Histone acetyltransferase p300Q09472Details