The DNA sequence of human chromosome 22.
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Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.
The DNA sequence of human chromosome 22.
Nature. 1999 Dec 2;402(6761):489-95.
- PubMed ID
- 10591208 [ View in PubMed]
- Abstract
Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Voltage-dependent T-type calcium channel subunit alpha-1I Q9P0X4 Details G protein-coupled receptor kinase 3 P35626 Details Peroxisome proliferator-activated receptor alpha Q07869 Details SEC14-like protein 4 Q9UDX3 Details NADH-cytochrome b5 reductase 3 P00387 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 P56556 Details Choline/ethanolamine kinase Q9Y259 Details SEC14-like protein 2 O76054 Details Chronophin Q96GD0 Details SEC14-like protein 3 Q9UDX4 Details Monocarboxylate transporter 3 O95907 Details Transcobalamin-2 P20062 Details 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial O75600 Details Interleukin-2 receptor subunit beta P14784 Details Phosphatidylserine decarboxylase proenzyme, mitochondrial Q9UG56 Details Heme oxygenase 1 P09601 Details Translocator protein P30536 Details Glutathione S-transferase theta-1 P30711 Details Glutathione hydrolase 1 proenzyme P19440 Details Mitogen-activated protein kinase 1 P28482 Details 85/88 kDa calcium-independent phospholipase A2 O60733 Details Tubulin alpha-8 chain Q9NY65 Details Catechol O-methyltransferase P21964 Details Cytokine receptor common subunit beta P32927 Details Thymidine phosphorylase P19971 Details Proline dehydrogenase 1, mitochondrial O43272 Details Cytochrome P450 2D6 P10635 Details Mitogen-activated protein kinase 12 P53778 Details Arylsulfatase A P15289 Details Galectin-2 P05162 Details Metalloproteinase inhibitor 3 P35625 Details Serine/threonine-protein kinase Chk2 O96017 Details Thioredoxin reductase 2, mitochondrial Q9NNW7 Details Mitogen-activated protein kinase 11 Q15759 Details Melanin-concentrating hormone receptor 1 Q99705 Details Platelet-derived growth factor subunit B P01127 Details Casein kinase I isoform epsilon P49674 Details Polyamine deacetylase HDAC10 Q969S8 Details Somatostatin receptor type 3 P32745 Details Stromelysin-3 P24347 Details Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Q8IVS2 Details Large ribosomal subunit protein uL3 P39023 Details NHP2-like protein 1 P55769 Details Cytochrome b-c1 complex subunit 9 Q9UDW1 Details Myocardin-related transcription factor A Q969V6 Details RNA-splicing ligase RtcB homolog Q9Y3I0 Details Meiotic recombination protein DMC1/LIM15 homolog Q14565 Details Thiosulfate sulfurtransferase Q16762 Details Myoglobin P02144 Details Parvalbumin alpha P20472 Details Galectin-1 P09382 Details Aconitate hydratase, mitochondrial Q99798 Details Glutathione S-transferase theta-2 P0CG29 Details Alpha-N-acetylgalactosaminidase P17050 Details Sodium/glucose cotransporter 1 P13866 Details Ras-related C3 botulinum toxin substrate 2 P15153 Details Neutrophil cytosol factor 4 Q15080 Details Cyclic AMP-dependent transcription factor ATF-4 P18848 Details Voltage-dependent calcium channel gamma-2 subunit Q9Y698 Details Inward rectifier potassium channel 4 P48050 Details Solute carrier family 2, facilitated glucose transporter member 11 Q9BYW1 Details TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 Details Ran-specific GTPase-activating protein P43487 Details 14-3-3 protein eta Q04917 Details Immunoglobulin lambda-like polypeptide 1 P15814 Details Apolipoprotein L1 O14791 Details Immunoglobulin lambda variable 3-21 P80748 Details Myosin-9 P35579 Details LIM domain kinase 2 P53671 Details Serine/threonine-protein kinase pim-3 Q86V86 Details Sulfotransferase 4A1 Q9BR01 Details P2X purinoceptor 6 O15547 Details V-type proton ATPase subunit E 1 P36543 Details Glutathione S-transferase theta-2B P0CG30 Details Histone acetyltransferase p300 Q09472 Details