Pore Forming Cytotoxic Proteins
- Pore Forming Cytotoxic Proteins
- Accession Number
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
Drug Drug Description Polymyxin B A polymyxin antibiotic used to treat a wide variety of infections in the body. Gramicidin D A bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections. Colistin A polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria. Colistimethate An antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa. Omiganan Investigated for use/treatment in bacterial infection and rosacea. Iseganan Iseganan is under investigation in clinical trial NCT00022373 (Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer). Pexiganan Pexiganan is under investigation in clinical trial NCT01594762 (Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers).
- Drugs & Drug Targets
Drug Target Type Polymyxin B Bacterial outer membrane target Polymyxin B Solute carrier family 15 member 2 transporter Gramicidin D P-glycoprotein 1 transporter Colistin Bacterial outer membrane target Colistimethate Bacterial outer membrane target