Pore Forming Cytotoxic Proteins

Name
Pore Forming Cytotoxic Proteins
Accession Number
DBCAT000102
Description

Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.

Drugs
DrugDrug Description
Polymyxin BA polymyxin antibiotic used to treat a wide variety of infections in the body.
Gramicidin DA bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.
ColistinA polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.
ColistimethateAn antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa.
OmigananInvestigated for use/treatment in bacterial infection and rosacea.
IsegananIseganan is under investigation in clinical trial NCT00022373 (Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer).
PexigananPexiganan is under investigation in clinical trial NCT01594762 (Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers).
Drugs & Drug Targets
DrugTargetType
Polymyxin BBacterial outer membranetarget
Polymyxin BSolute carrier family 15 member 2transporter
Gramicidin DP-glycoprotein 1transporter
ColistinBacterial outer membranetarget
ColistimethateBacterial outer membranetarget