Pore Forming Cytotoxic Proteins

DBCAT000102Pharmacologic class

Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. A DrugBank category of 10 drugs. 4 of them are approved.

Drugs: Colistimethate
Colistin
Gramicidin D
Iseganan
Nisin Z
Omiganan
P-113D
Pexiganan
Polymyxin B
Ropocamptide

What you can answer from here — as of August 24, 2016

10DrugsEach linked to its full drug card

Listed above

9Drug targetsEvery drug–target pair in the class, with bond type

1,479Marketed productsAcross the regions we cover, with dosage forms and routes

20Routes of administrationHow the drugs in this class are given

Which targets do Pore Forming Cytotoxic Proteins share, and which companies have late-stage candidates in this class?

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