- Accession Number
Drug Drug Description Dornase alfa A synthetic form of human deoxyribonuclease I used to break down extracellular DNA in the lungs, a major source of mucous viscosity in cystic fibrosis. Pancrelipase A purified form of porcine pancreatic lipase, amylase, and protease enzymes used to treat malabsorption associated with pancreatic insufficiency resulting from cystic fibrosis and pancreatitis. Idursulfase A purified lysosomal enzyme used as a replacement therapy for Hunter syndrome in pediatric and adult patients. Galsulfase A recombinant human enzyme used as replacement enzyme therapy for the treatment of of adults and children with Mucopolysaccharidosis VI, a rare genetic disorder caused by a deficiency of a lysosomal enzyme. Ranpirnase For the treatment of various forms of cancer. ALTU-135 Investigated for use/treatment in cystic fibrosis and pancreatic disorders. Alkaline Phosphatase Investigated for use/treatment in ulcerative colitis. Elosulfase alfa A lysosomal glycosaminoglycan (GAG)-specific enzyme indicated as an enzyme replacement therapy for Mucopolysaccharidosis type IV A. Asfotase alfa An enzyme replacement therapy used for the treatment of perinatal/infantile and juvenile onset hypophosphatasia (HPP). Sebelipase alfa A recombinant lysosomal acid lipase used to treat lysosomal acid lipase deficiency. Olipudase alfa Olipudase alfa has been used in trials studying the treatment of Sphingomyelin Lipidosis and Human Acid Sphingomyelinase Deficiency. Pancrelipase lipase A lipase used to treat pancreatic exocrine insufficiency. Desoxyribonuclease Desoxyribonuclease is a crystalline enzyme that aids in the digestion of the thymus nucleic acid. The mechanism of action of the enzyme involves the splitting of thymus nucleic acid into... Deoxyribonuclease I Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7 . It is normally found in saliva, urine, pancreatic secretions, and blood . Because of...
- Drugs & Drug Targets
Drug Target Type Dornase alfa DNA target Pancrelipase Dietary fat target Pancrelipase Dietary protein target Pancrelipase Dietary starch target Idursulfase Perilipin-3 target Idursulfase Dermatan sulfate target Idursulfase Heparan sulfate target Galsulfase Perilipin-3 target Galsulfase Dermatan sulfate target Ranpirnase DNA target Asfotase alfa Pyrophosphate target Pancrelipase lipase Dietary fat target