- Growth Substances
- Accession Number
Signal molecules that are involved in the control of cell growth and differentiation.
Drug Drug Description Becaplermin A recombinant form of human platelet-derived growth factor used to treat ulcers due to diabetic neuropathy in the lower extremities when there is adequate blood supply to the area. Pyridoxal phosphate A vitamin available in many formulations to correct vitamin B6 deficiency. Cyanocobalamin A vitamin available in many formulations to correct vitamin B12 deficiency. Biotin A B-complex vitamin found in many multivitamin products. Ascorbic acid A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron. Calcitriol An active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Riboflavin A vitamin used to correct vitamin B2 deficiency. Calcifediol An active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients. Pyridoxal Pyridoxal is one of the natural forms available of vitamin B6, therefore, it is used for nutritional supplementation and for treating dietary shortage or imbalances. Thiamine A vitamin used to correct vitamin B1 deficiency. Ergocalciferol A vitamin found in many supplement products. Vitamin A A vitamin important for retinal function that is used clinically to correct vitamin A deficiency. Vitamin E An antioxidant vitamin used in many skin creams and multivitamin preparations. Lipoic acid For nutritional supplementation, also for treating dietary shortage or imbalance. Cholecalciferol A form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease. Menadione The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. Hydroxocobalamin A synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning. Lenalidomide A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome. Niacin A B vitamin used to treat hypertriglyceridemia and pellagra. Leucovorin A folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer. Phylloquinone A fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. Thalidomide A medication used to treat newly diagnosed multiple myeloma and erythema nodosum leprosum. Dihydrotachysterol A synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3. Sunitinib A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Ranibizumab A recombinant humanized monoclonal antibody and VEGF-A antagonist used for the management of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema. Iron An essential element commonly used for the treatment of patients with documented iron deficiency. Zinc An essential element commonly used for the treatment of patients with documented zinc deficiency. Pantothenic acid A vitamin B5 found in various nutritional supplements. Fumagillin Not Available Nicotinamide An ingredient found in a variety of cosmetic products. Alvocidib Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified). Halofuginone For the treatment of scleroderma, cancer, and restenosis. Tetrathiomolybdate Investigated for use/treatment in liver disease and pulmonary fibrosis. Iodine An ingredient of nutritional supplements that is also used for disinfection. Oglufanide Investigated for use/treatment in hepatitis (viral, C). Doxercalciferol A synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis. Endostatin Investigated for use/treatment in cancer/tumors (unspecified), macular degeneration, and diabetic retinopathy. Semaxanib Investigated for use/treatment in colorectal cancer and lung cancer. Squalamine Investigated for use/treatment in ovarian cancer, lung cancer, and macular degeneration. Beta carotene A vitamin A precursor found in various nutritional supplements and health products. Manganese A transition metal used for supplementation of manganese during Total Parenteral Nutrition (TPN). Gibberellic acid Not Available Dehydroascorbic acid There is no approved indication for dehydroascorbic acid, but it has potential therapeutic use in patients with certain viruses and ischemic stroke. Acetylcarnitine Acetylcarnitine is not approved for any indication in the United states and Canada, but it is approved and indicated in Italy for cerebrovascular disorders, mental function disorders, peripheral nerve disorders,... Pomalidomide A thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma. Fursultiamine Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative. Copper A transition metal found in a variety of supplements and vitamins, including intravenous solutions for total parenteral nutrition (TPN). Nicorandil A vasodilatory drug that functions through potassium channels and intracellular cGMP concentrations commonly used to treat angina. Ubidecarenone A cofactor found in various dietary supplements. Selenic acid An ingredient found in a variety of supplements and vitamins. Vitamin D An ingredient found in a variety of supplements and vitamins. Selenious acid An ingredient found in supplements, vitamins, parenteral nutrition, and dandruff shampoo. Cupric oxide An ingredient found in a variety of supplements and vitamins. Selenium An ingredient found in a variety of supplements and vitamins. Chromium An ingredient found in a variety of supplements and vitamins. Molybdenum An ingredient found in a variety of supplements and vitamins. Boron Boron (B) is a chemical element with an atomic number 5 that belongs in the Period 2 and Group 13 in the periodic table. It is a low-abundant metalloid that... Tocopherol Tocopherol can be used as a dietary supplement for patients with a deficit of vitamin E; this is mainly prescribed in the alpha form. Vitamin E deficiency is rare, and... Prezatide Commonly used in cosmetic products for the skin and hair . Cod liver oil An ingredient found in a variety of nutritional products. Kinetin Kinetin is a cytokinin which are plant hormones promotes cell division and plant growth. It was shown to naturally exist in DNA of organisms including humans and various plants. While... Zeatin An aminopurine factor in plant extracts that induces cell division. (Grant & Hackh's Chemical Dict, 5th ed) Roquinimex Roquinimex is investigated to be used as a treatment of a number of cancers and autoimmune conditions. As well, roquinimex is researched to be used as adjuvant therapy after bone... Avilamycin Not Annotated Ractopamine Not Annotated Pyridoxamine Pyridoxamine has been used in trials studying the treatment of Kidney Stones. Trebananib Trebananib is under investigation for the treatment of Ovarian Cancer, Peritoneal Cancer, and Fallopian Tube Cancer. Trebananib has been investigated for the treatment of Cancer, Oncology, Carcinoma, Metastases, and Colon... Anecortave Anecortave is under investigation in clinical trial NCT00691717 (Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension). Tocotrienol Tocotrienol has been investigated for the treatment of Cholesterol Lowering. Silicon Silicon is under investigation in clinical trial NCT00103246 (Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II... Inositol An ingredient found in a variety of nutritional products. Vanadium A micronutrient used in some multivitamins and parenteral nutrition. alpha-Tocopherol succinate A form of vitamin E used to treat and prevent vitamin deficiencies. alpha-Tocopherol acetate A form of vitamin E used to treat and prevent vitamin deficiencies. Cobalamin Not Annotated Calcium ascorbate Not Available Ferrous fumarate A medication used to treat iron-deficiency anemia. Cobalt A metal element used in various nutritional products. Indoleacetic acid Not Available Cocarboxylase The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Flavin mononucleotide A form of vitamin B2 used to restore riboflavin in anemia, migraine, alcoholism, and hyperhomocysteinemia. TNP-470 O-(chloroacetylcarbamoyl)fumagillol (TNP-470) has been used in trials studying the treatment of HIV Infections, Sarcoma, Kaposi, and Pancreatic Neoplasms. Menaquinone 6 Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2). Menaquinone Menaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists). gamma-Tocopherol gamma-Tocopherol is under investigation in clinical trial NCT00836368 (In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics). Mecasermin A recombinant insulin-like growth factor-1 used for the long-term treatment of growth failure in pediatric patients with primary IGF-1 deficiency or with growth hormone gene deletion due to the development of neutralizing antibodies to GH. Ergosterol A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS... Volociximab Investigated for use/treatment in solid tumors, renal cell carcinoma, melanoma, pancreatic cancer, lung cancer, and ovarian cancer. Tesamorelin A growth hormone releasing factor (GRF) analog used to reduce excessive abdominal fat in HIV patients who have developed lipodystrophy. Endostar Endostar is under investigation for the treatment of Nasopharyngeal Carcinoma. Endostar has been investigated for the treatment of Non-small Cell Lung Cancer. Beloranib Beloranib has been used in trials studying the treatment of Obesity, Over-weight, Type 2 Diabetes, Craniopharyngioma, and Hypothalamic Injury, among others. Folic acid A nutrient used to treat megaloblastic anemia and is found in many supplements. Ubiquinone Q2 Not Available Edodekin alfa Edodekin alfa is under investigation in clinical trial NCT01468896 (Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That Is Recurrent, Metastatic, or... Cryptoxanthin Not Annotated Menadione bisulfite Not Annotated Monophosphothiamine A B vitamin for supplementation to treat macrocytic anemia, and other conditions caused by B vitamin deficiencies.
- Drugs & Drug Targets