Uterotonic agents

Name
Uterotonic agents
Accession Number
DBCAT000218  (DBCAT002138)
Description

Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)

ATC Classification
Drugs
DrugDrug Description
OxytocinA recombinant hormone used to induce or strengthen uterine contractions in pregnant women to aid in labor and delivery or to control postpartum bleeding.
CarbetocinAn oxytocin agent used to control postpartum hemorrhage and bleeding after giving birth.
Carboprost tromethamineA prostaglandin used to treat postpartum uterine hemorrhage due to atony when other methods of management have not been effective.
DinoprostoneA prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease.
Dinoprost tromethamineUsed for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities...
ErgometrineAn ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony.
MethylergometrineAn ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery.
ErgotamineAn alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches.
MisoprostolA prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers.
DinoprostA medication used to induce a second trimester abortion.
DemoxytocinNot Annotated
GemeprostA prostaglandin E1 analogue used for cervical dilation and, in combination with mifepristone, for pregnancy termination.
SulprostoneA prostaglandin analogue used to treat post-partum hemorrhaging, induce medical abortion, and induce labour in instances of in utero fetal death.
Drugs & Drug Targets
DrugTargetType
OxytocinOxytocin receptortarget
OxytocinProlyl endopeptidaseenzyme
OxytocinOxytocin-neurophysin 1carrier
OxytocinLeucyl-cystinyl aminopeptidaseenzyme
OxytocinAdvanced glycosylation end product-specific receptortransporter
CarbetocinOxytocin receptortarget
Carboprost tromethamineProstaglandin E2 receptor EP1 subtypetarget
DinoprostoneProstaglandin E2 receptor EP2 subtypetarget
DinoprostoneProstaglandin E2 receptor EP1 subtypetarget
DinoprostoneProstaglandin E2 receptor EP4 subtypetarget
DinoprostoneProstaglandin E2 receptor EP3 subtypetarget
DinoprostoneSolute carrier family 22 member 2transporter
DinoprostoneMultidrug resistance-associated protein 5transporter
DinoprostoneSolute carrier family 22 member 6transporter
DinoprostoneSolute carrier family 22 member 8transporter
DinoprostoneSolute carrier family 22 member 11transporter
DinoprostoneSolute carrier family 22 member 7transporter
DinoprostoneMultidrug resistance-associated protein 4transporter
DinoprostoneSolute carrier organic anion transporter family member 2B1transporter
DinoprostoneSolute carrier organic anion transporter family member 1A2transporter
DinoprostoneOrganic solute transporter subunit alphatransporter
DinoprostoneOrganic solute transporter subunit betatransporter
DinoprostoneSolute carrier organic anion transporter family member 2A1transporter
DinoprostoneSolute carrier organic anion transporter family member 4A1transporter
DinoprostoneSolute carrier organic anion transporter family member 1C1transporter
DinoprostoneSolute carrier organic anion transporter family member 3A1transporter
DinoprostoneSolute carrier organic anion transporter family member 1B1transporter
DinoprostoneProstaglandin D2 receptor 2target
Dinoprost tromethamineProstacyclin receptortarget
Dinoprost tromethamineProstaglandin F2-alpha receptortarget
Dinoprost tromethamineSolute carrier family 22 member 2transporter
Dinoprost tromethamineSolute carrier family 22 member 6transporter
Dinoprost tromethamineSolute carrier family 22 member 7transporter
Dinoprost tromethamineSolute carrier family 22 member 8transporter
Dinoprost tromethamineSolute carrier family 22 member 11transporter
Dinoprost tromethamineSolute carrier organic anion transporter family member 2A1transporter
Dinoprost tromethamineSolute carrier organic anion transporter family member 3A1transporter
ErgometrineCytochrome P450 3A4enzyme
ErgometrineP-glycoprotein 1transporter
ErgometrineAlpha-1A adrenergic receptortarget
MethylergometrineDopamine D1 receptortarget
MethylergometrineCytochrome P450 3A4enzyme
Methylergometrine5-hydroxytryptamine receptor 2Btarget
ErgotamineAlpha-1A adrenergic receptortarget
Ergotamine5-hydroxytryptamine receptor 1Dtarget
Ergotamine5-hydroxytryptamine receptor 1Btarget
Ergotamine5-hydroxytryptamine receptor 2Atarget
ErgotamineAlpha-2A adrenergic receptortarget
ErgotamineDopamine D2 receptortarget
ErgotamineCytochrome P450 3A4enzyme
ErgotamineAlpha-1B adrenergic receptortarget
ErgotamineAlpha-1D adrenergic receptortarget
ErgotamineP-glycoprotein 1transporter
ErgotamineD(1) dopamine receptortarget
Ergotamine5-hydroxytryptamine receptor 1Atarget
Ergotamine5-hydroxytryptamine receptor 1Ftarget
Ergotamine5-hydroxytryptamine receptor 2Ctarget
Ergotamine5-hydroxytryptamine receptor 2Btarget
ErgotamineAlpha-2C adrenergic receptortarget
MisoprostolProstaglandin E2 receptor EP2 subtypetarget
MisoprostolProstaglandin E2 receptor EP3 subtypetarget
MisoprostolProstaglandin E2 receptor EP4 subtypetarget
MisoprostolProstaglandin E2 receptor EP1 subtypetarget
DinoprostProstaglandin D2 receptor 2target
GemeprostProstaglandin E2 receptor EP2 subtypetarget
GemeprostProstaglandin E2 receptor EP3 subtypetarget